Frequencies of CYP2C9 polymorphisms in a Syrian cohort
This study provides evidence for high prevalence of the CYP2C9 *2 and *3 alleles, and consequently the intermediate and poor metabolizer phenotypes in Syrians. Two rare putative function-relevant variants (*41 and *46) were detected in three individuals. These findings pave the path to the efforts for implementing CYP2C9 pharmacogenetics-based personalized pharmacotherapy in this Middle Eastern population.
Authors
- Weam Aldiban (ORCID: https://orcid.org/0000-0001-7485-8147)
- Lama A. Youssef (ORCID: https://orcid.org/0000-0001-8013-7856)
- Majd Aljamali (ORCID: https://orcid.org/0000-0001-7422-1699)
Institutions
- Damascus Hospital (SY)
- Arab International University (SY)
- International University for Science and Technology (SY)
- Atomic Energy Commission of Syria (SY)
- Damascus University (SY)
Publication Details
- Journal
- BMC Genomics
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1186/s12864-025-11310-9
- Citations
- 2
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- Damascus University