GSDMD Deficiency Attenuates the Development of Ascending Aortic Dissections in a Novel Mouse Model

A novel mouse TAD model was developed, specifically targeting the ascending aorta. This model generates a unique microenvironment that activates specific immune cell subsets, driving the onset and subsequent remodeling of TADs. Consistently, Gsdmd deficiency mitigates TAD development, likely by modulating cell death and T-cell responses. This model provides a valuable tool for studying immune injury mechanisms in TAD pathogenesis.

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Publication Details

Journal
Arteriosclerosis Thrombosis and Vascular Biology
Published
2025-02-13
DOI
https://doi.org/10.1161/atvbaha.124.321740
Primary Topic
Aortic Disease and Treatment Approaches
Type
article
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article

GSDMD Deficiency Attenuates the Development of Ascending Aortic Dissections in a Novel Mouse Model

Marvin L. Dirain, Gang Su, Gilbert R. Upchurch, Guoshuai Cai et al.
Arteriosclerosis Thrombosis and Vascular Biology
Aortic Disease and Treatment Approaches
article

GSDMD Deficiency Attenuates the Development of Ascending Aortic Dissections in a Novel Mouse Model

Marvin L. Dirain, Gang Su, Gilbert R. Upchurch, Guoshuai Cai, Muhammad J. Javed, Zhihua Jiang, Laura Carrasco, Rachael M. Howard, Hua Li
article en

Abstract

A novel mouse TAD model was developed, specifically targeting the ascending aorta. This model generates a unique microenvironment that activates specific immune cell subsets, driving the onset and subsequent remodeling of TADs. Consistently, Gsdmd deficiency mitigates TAD development, likely by modulating cell death and T-cell responses. This model provides a valuable tool for studying immune injury mechanisms in TAD pathogenesis.

Arteriosclerosis Thrombosis and Vascular BiologyVol. 45(4)
University of Florida (US), Malcom Randall VA Medical Center (US), University of Florida Health Science Center (US), Florida College (US)
Good health and well-being
Openalex Percentile: Top 96%
Aortic Disease and Treatment Approaches
DOISourceOpenAlex
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GSDMD Deficiency Attenuates the Development of Ascending Aortic Dissections in a Novel Mouse Model — Marvin L. Dirain, Gang Su, et al. · Arteriosclerosis Thrombosis and Vascular Biology (2025) | TGRS Research Map | TGRS