Effect of Initiation and Continuous Adherence to ARBs Versus ACEIs on Risk of Adjudicated Mild Cognitive Impairment or Dementia
In this target trial emulation of older adults at high risk for cardiovascular disease, there was insufficient evidence to conclude a beneficial effect of initiating and continuously adhering to an ARB versus ACEI on adjudicated clinical cognitive outcomes.
Authors
- Tom Greene (ORCID: https://orcid.org/0000-0002-3706-7570)
- Daniel O. Scharfstein (ORCID: https://orcid.org/0000-0001-7482-9653)
- Catherine G. Derington (ORCID: https://orcid.org/0000-0001-7382-4607)
- Yizhe Xu (ORCID: https://orcid.org/0000-0002-0773-1709)
- Jeff D. Williamson (ORCID: https://orcid.org/0000-0002-0185-5823)
- Ransmond O. Berchie (ORCID: https://orcid.org/0000-0001-6883-6822)
- Nicholas M. Pajewski (ORCID: https://orcid.org/0000-0002-4447-6196)
- Jeremy J. Pruzin (ORCID: https://orcid.org/0000-0002-0443-4194)
- Ryan M. Andrews (ORCID: https://orcid.org/0000-0002-7750-2397)
- Adam P. Bress (ORCID: https://orcid.org/0000-0002-2259-5039)
- Joshua A. Sonnen (ORCID: https://orcid.org/0000-0001-9267-8705)
- Mark A. Supiano (ORCID: https://orcid.org/0000-0002-5438-5087)
- Jordan B. King (ORCID: https://orcid.org/0000-0002-6783-7951)
- Jordana B. Cohen (ORCID: https://orcid.org/0000-0003-4649-079X)
Institutions
- Intermountain Healthcare (US)
- Boston University (US)
- Alzheimer's Association (US)
- Kaiser Permanente (US)
- University of Utah (US)
- Banner Health (US)
- Utah Cancer Specialists (US)
- Kaiser Permanente Center for Health Research (US)
- George E. Wahlen Department of VA Medical Center (US)
- Wake Forest University (US)
- McGill University (CA)
- University of Pennsylvania (US)
Publication Details
- Journal
- The Journals of Gerontology Series A
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1093/gerona/glaf028
- Citations
- 5
- Primary Topic
- Blood Pressure and Hypertension Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.94
Funders
- American Heart Association
- National Institutes of Health
- Directorate for Biological Sciences
- National Institute on Aging
- National Heart, Lung, and Blood Institute
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Center for Research Resources
- National Center for Advancing Translational Sciences