Detection of the 30-bp deletion and protein expression of Epstein-Barr virus latent membrane protein 1 in extranodal NK/T cell lymphoma and its clinicopathological significance
In this retrospective cohort, we demonstrated that del-LMP1 might be the predominant variant rather than a phenotype-associated polymorphism in ENKTCL from a molecular epidemiological perspective. Moreover, LMP1 protein expression was associated with necrotic tissue and younger patients with del-LMP1, possibly due to the enhanced pathogenic effect of the mutated LMP1 isolate protein.
Authors
- Sui‐Dan Chen (ORCID: https://orcid.org/0000-0002-5226-8573)
- Xiuhuan Ji
- Xingmei Lu (ORCID: https://orcid.org/0009-0002-0803-2018)
- Rixu Lin (ORCID: https://orcid.org/0000-0003-2498-8116)
- Kate Huang (ORCID: https://orcid.org/0000-0002-8553-1817)
- Xiaoyu Wang (ORCID: https://orcid.org/0000-0002-0861-0204)
- Peng Li (ORCID: https://orcid.org/0000-0003-4530-2400)
- Qingsong Han
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Wenzhou Vocational College of Science and Technology (CN)
Publication Details
- Journal
- Diagnostic Pathology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1186/s13000-025-01607-4
- Primary Topic
- Viral-associated cancers and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Science and Technology Plan Project of Wenzhou, China