Comparative In silico and In vitro Studies of Novel Zinc/Tin Metal Coordinates Bearing BRCA-1 Mimetics on WTp53 and MTp53 Proteins
As compared to PRIMA-1, the designed compound TSCO5 metal coordinates have shown good <i>in silico</i> and in vitro activity on mutated p53 cell lines and are more potent than the p53 activator PRIMA-1.
Authors
- R Saranya
- Preeya Negi (ORCID: https://orcid.org/0000-0002-1640-7986)
- M. Esakkimuthukumar
- Jawahar Natarajan
- Akey Krishna Swaroop (ORCID: https://orcid.org/0000-0003-2696-4193)
- Jubie Selvaraj (ORCID: https://orcid.org/0000-0002-4633-6621)
- Anuj Kumar Singh (ORCID: https://orcid.org/0000-0002-3602-5969)
- P. Vasanth Raj
Institutions
- JSS Academy of Higher Education and Research (IN)
Publication Details
- Journal
- Protein and Peptide Letters
- Published
- 2025-02-13
- DOI
- https://doi.org/10.2174/0109298665361116250121103146
- Citations
- 1
- Primary Topic
- Biotechnology and Related Fields
- Type
- article
- Field-Weighted Citation Impact
- 1.88