Bioinformatics Analysis of Key Genes Associated with Resistance to the Combination of Bevacizumab and Pemetrexed Chemotherapy in Non-small Cell Lung Cancer
The identification of key genes, such as TNFSF4, and resistance-related signaling pathways through bioinformatics analysis offers valuable insights into potential mechanisms of chemotherapy resistance in NSCLC when treated with the combination of bevacizumab and pemetrexed. These findings provide a theoretical foundation for advancing clinical research on diagnosis and treatment.
Authors
- Shenjie Xu
- Chenling Hu
- Siwen Chen (ORCID: https://orcid.org/0000-0003-2732-4286)
- Qian Sun (ORCID: https://orcid.org/0000-0002-1068-1933)
- Xudong Pan (ORCID: https://orcid.org/0009-0009-1010-9142)
Institutions
- Nanjing General Hospital of Nanjing Military Command (CN)
- Soochow University (CN)
- First Affiliated Hospital of Soochow University (CN)
- Nanjing Medical University (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Recent Patents on Anti-Cancer Drug Discovery
- Published
- 2025-02-13
- DOI
- https://doi.org/10.2174/0115748928376905250210055408
- Primary Topic
- Lung Cancer Treatments and Mutations
- Type
- article
- Field-Weighted Citation Impact
- 0.00