Single‐Cell Analysis of Endothelial Cell Injury in IgA Nephropathy
This study presents novel findings regarding the contribution of renal endothelial cells to the development of IgAN, as it demonstrates that IL-6 negatively regulates VE-cad expression in HRGECs via Rac1. These results highlight the significant involvement of renal endothelial cells in the pathogenesis of IgAN.
Authors
- Chengguang Zhao (ORCID: https://orcid.org/0000-0002-4783-5238)
- Yongchang Yang (ORCID: https://orcid.org/0000-0002-2692-5744)
- Lin Zhu
- Ping Zhou (ORCID: https://orcid.org/0000-0001-9680-1651)
- Bo Zhang (ORCID: https://orcid.org/0000-0002-0804-6404)
- Wai W. Cheung
- Xiao‐Meng Wang
- Jing‐Ying Zhao
Institutions
- Chengdu Medical College (CN)
- University of California San Diego (US)
- Rady Children's Hospital-San Diego (US)
- Chengdu Women's and Children's Central Hospital (CN)
- China Medical University (CN)
- Tsinghua University (CN)
Publication Details
- Journal
- Immunity Inflammation and Disease
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1002/iid3.70149
- Primary Topic
- Renal Diseases and Glomerulopathies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Department of Science and Technology of Sichuan Province
- Health Commission of Sichuan Province