Selective Effects of Substantia Nigra and Locus Coeruleus Degeneration on Cognition in Parkinson's Disease
These results suggest that SN and LC degeneration may contribute to different cognitive deficits, potentially explaining the heterogeneity that exists in the cognitive manifestations of PD. These results also highlight the potential value of leveraging brain-behavior relationships to develop performance-based measures of cognition that could be used to characterize the phenotypic differences associated with underlying patterns of neurodegeneration. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Jelena Djordjevic (ORCID: https://orcid.org/0000-0001-9769-6857)
- Sophie Sun (ORCID: https://orcid.org/0000-0001-8448-6519)
- Jean‐François Gagnon (ORCID: https://orcid.org/0000-0003-1132-0563)
- Madeleine E. Sharp (ORCID: https://orcid.org/0000-0001-6289-9128)
- Alain Dagher (ORCID: https://orcid.org/0000-0002-0945-5779)
- D. Louis Collins (ORCID: https://orcid.org/0000-0002-8432-7021)
- Victoria Madge (ORCID: https://orcid.org/0000-0003-2027-2911)
Institutions
- Montreal Neurological Institute and Hospital (CA)
- Université du Québec à Montréal (CA)
- Hôpital du Sacré-Cœur de Montréal (CA)
- Centre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-Montréal (CA)
- McGill University (CA)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1002/mds.30148
- Citations
- 7
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 9.72
Funders
- Canadian Institutes of Health Research