Impact of olive tree extract on hyperlipidemia in rats: HPLC analysis of bioactive constituents

Dyslipidemia, characterized by abnormal blood lipid levels, is a significant risk factor for cardiovascular diseases (CVDs). Natural plant extracts, particularly olive extract, have garnered attention for their potential therapeutic effects. This study investigates the hypolipidemic effects of olive tree extract (OTE) in hyperlipidemic rats. Male Wistar rats were fed a hypercholesterolemic diet for two weeks, followed by three weeks of daily treatment with OTE. The results indicate that OTE effectively reduced triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) levels while elevating high-density lipoprotein cholesterol (HDL-C) levels. Furthermore, OTE demonstrated superior efficacy in improving lipid profiles compared to simvastatin, a commonly used lipid-lowering drug. Additionally, OTE administration positively influenced the heart disease risk ratio and normalized renal function parameters. These findings underscore the potential of OTE as a natural intervention for managing dyslipidemia and reducing the risk of CVDs. Overall, OTE exhibits promising hypolipidemic properties, highlighting its therapeutic potential in addressing lipid disorders and associated cardiovascular risks.