Bosentan as adjunctive therapy in neonates with congenital diaphragmatic hernia-associated pulmonary hypertension: a case series
• This case series of 50 CDH neonates receiving bosentan demonstrates an improvement in PH severity based on echocardiographic assessment in 54% within one week of treatment. • Respiratory support modus (i.e. ECMO, mechanical ventilation, CPAP) improved significantly within two weeks of bosentan treatment in responders and non-responders.
Authors
- Florian Kipfmueller (ORCID: https://orcid.org/0000-0002-7414-757X)
- Bartolomeo Bo (ORCID: https://orcid.org/0000-0002-5187-1346)
- Lotte Lemloh
- Neil Patel (ORCID: https://orcid.org/0000-0002-7296-6731)
- Andreas Müeller (ORCID: https://orcid.org/0000-0002-5619-1550)
- Lennart Hale
- Aster de Vadder
Institutions
- University of Bonn (DE)
- University Hospital Bonn (DE)
- Royal Hospital for Children (GB)
Publication Details
- Journal
- European Journal of Pediatrics
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1007/s00431-025-06019-6
- Citations
- 3
- Primary Topic
- Congenital Diaphragmatic Hernia Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- Rheinische Friedrich-Wilhelms-Universität Bonn