Physiological responses to retinopathy of prematurity screening: indirect ophthalmoscopy versus ultra-widefield retinal imaging
ROP screening can be distressing for premature infants and induce physiological instability during and after the examination. We deployed non-contact ultra-widefield retinal imaging as the default method of ROP screening and show that it induces comparable physiological responses as traditional indirect ophthalmoscopy in non-ventilated babies. Dandle WRAP swaddling facilitated handling and speed of retinal imaging. The study demonstrates that imaging-based ROP screening is safe and efficacious in non-ventilated neonates, and continuous multimodal physiological recordings can provide detailed assessment of the effects of procedures and medications.
Authors
- Caroline Hartley (ORCID: https://orcid.org/0000-0002-7981-0836)
- Amanda Clifford
- Marianne van der Vaart (ORCID: https://orcid.org/0000-0001-8628-8719)
- Miranda Buckle (ORCID: https://orcid.org/0000-0002-6722-7125)
- Luke Baxter (ORCID: https://orcid.org/0000-0001-9548-7162)
- Fatima Usman (ORCID: https://orcid.org/0000-0002-8761-953X)
- Ravi Purohit (ORCID: https://orcid.org/0000-0002-9727-5275)
- Rebeccah Slater (ORCID: https://orcid.org/0000-0003-1595-4846)
- Kanmin Xue (ORCID: https://orcid.org/0000-0003-0065-9131)
- Shellie Robinson
- Eleri Adams (ORCID: https://orcid.org/0000-0002-7034-1287)
- Amanda Ie
- Chetan K. Patel
- Michelle Clee
Institutions
- Great Ormond Street Hospital for Children NHS Foundation Trust (GB)
- Nuffield Orthopaedic Centre (GB)
- University of Oxford (GB)
- Oxford University Hospitals NHS Trust (GB)
Publication Details
- Journal
- Pediatric Research
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1038/s41390-025-03906-4
- Citations
- 2
- Primary Topic
- Retinopathy of Prematurity Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.72
Funders
- Wellcome Trust
- National Institute for Health and Care Research
- Commonwealth Scholarship Commission