Acetyltransferase NAT10 promotes gastric cancer progression by regulating the Wnt/β-catenin signaling pathway and enhances chemotherapy resistance
Our findings indicated that expression of NAT10 promoted GC progression through activation of the Wnt/β-catenin signaling pathway. We investigated the effect of NAT10 on the viability of GC cells treated with different doses of cisplatin. The results showed that NAT10 expression could impact the effectiveness of chemotherapy resistance in GC. This implies that using NAT10 as a target may be a potential therapeutic strategy for treating GC.
Authors
- Mingxu Da (ORCID: https://orcid.org/0000-0001-9181-6088)
- Zaihua Yan
- Qiong Wu
- Jieyun Gao
- Jian Yang (ORCID: https://orcid.org/0000-0001-7876-9475)
- Haoyang Zhang (ORCID: https://orcid.org/0000-0002-6937-7936)
- Xiujuan Huang
- Ya‐Wen Chen (ORCID: https://orcid.org/0000-0003-2382-8444)
- Yadan Du
- Bowen Nian
Institutions
- Shanxi Medical University (CN)
- Gansu University of Traditional Chinese Medicine (CN)
- Huaian First People’s Hospital (CN)
- Affiliated Hospital of North Sichuan Medical College (CN)
- Gansu Provincial Hospital (CN)
- Shanxi Provincial People’s Hospital (CN)
- First Hospital of Lanzhou University (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1007/s12672-025-01917-5
- Citations
- 3
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Gansu Province