Preliminary Data on the Senolytic Effects of Agrimonia pilosa Ledeb. Extract Containing Agrimols for Immunosenescence in Middle-Aged Humans: A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Comparison Study
APE was suggested to reduce senescent immune cells, indicating its potential as a candidate senolytic agent for humans; however, the results of this study are preliminary data, and further research on APE is needed (clinical trial registration: UMIN000051574).
Authors
- Yoshie Hirose
- Tsuyoshi Sakurada
- Yoshiki Shimizu (ORCID: https://orcid.org/0000-0002-2991-1356)
- Jiro Saito
- Misato Yazaki (ORCID: https://orcid.org/0000-0002-8876-291X)
- Sachiyuki Teramoto
- Tomomichi Watanabe (ORCID: https://orcid.org/0009-0009-2602-3896)
- Yuri Ishii
- Mariko Hayashida
- Shieri Shimodan
Institutions
- Fanuc (Japan) (JP)
- Kishokai Medical Corporation (JP)
Publication Details
- Journal
- Nutrients
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3390/nu17040667
- Citations
- 2
- Primary Topic
- Telomeres, Telomerase, and Senescence
- Type
- article
- Field-Weighted Citation Impact
- 2.33