Identification of Key Genes in Esketamine’s Therapeutic Effects on Perioperative Neurocognitive Disorders via Transcriptome Sequencing
We uncovered the therapeutic efficacy of esketamine in treating PND and identified 5 key genes (Ank1, Cbln4, L1cam, Gap43, and Shh) that contribute to its therapeutic effects, providing a valuable reference for further mechanistic studies on esketamine's treatment of PND.
Authors
- Shengguo Zhao (ORCID: https://orcid.org/0009-0000-7243-9563)
- Bailong Hu (ORCID: https://orcid.org/0000-0003-1126-5381)
- Jieqiong Luo
- Yang Luo (ORCID: https://orcid.org/0000-0001-7385-6166)
- Wen Hu (ORCID: https://orcid.org/0000-0002-4329-6900)
- Xiaohua Zou (ORCID: https://orcid.org/0000-0002-3489-9152)
- Xiaoyuan Zhang (ORCID: https://orcid.org/0000-0001-5130-9495)
- Hui Li (ORCID: https://orcid.org/0000-0003-4759-1779)
- Zhenhua Wu (ORCID: https://orcid.org/0000-0003-4552-883X)
- Qian Yang
Institutions
- Guiyang Medical University (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/dddt.s510752
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00