Association of fibrotic-related extracellular vesicle microRNAs with lung involvement in systemic sclerosis
Our small extracellular vesicle-based biomarker approach identified a promising four‑miRNA signature characteristic of interstitial lung disease in systemic sclerosis patients. Furthermore, the profibrotic properties of small extracellular vesicles associated with systemic sclerosis-associated interstitial lung disease suggest a prominent role of these vesicles in systemic sclerosis severity.
Authors
- Pierre Jacquerie
- Pieter van Paassen (ORCID: https://orcid.org/0000-0001-9366-7995)
- Serge Cremers (ORCID: https://orcid.org/0000-0002-6800-5532)
- Barbara Polese (ORCID: https://orcid.org/0000-0002-4400-6477)
- Rachid Tobal (ORCID: https://orcid.org/0009-0005-8255-4801)
- Renaud Louis (ORCID: https://orcid.org/0000-0002-4737-9084)
- Claire Remacle (ORCID: https://orcid.org/0000-0002-5016-9547)
- Malik Hamaïdia (ORCID: https://orcid.org/0000-0003-0459-4005)
- Julien Guiot (ORCID: https://orcid.org/0000-0001-7800-1730)
- Catherine Moermans (ORCID: https://orcid.org/0000-0002-9558-5878)
- Ingrid Struman (ORCID: https://orcid.org/0000-0003-2550-3707)
- Makon‐Sébastien Njock (ORCID: https://orcid.org/0000-0001-8137-1978)
- Dominique de Seny
- Fanny Gester
- Laurie Giltay
- Édouard Louis (ORCID: https://orcid.org/0000-0002-1287-7075)
- Judith Potjewijd (ORCID: https://orcid.org/0000-0001-9730-9298)
- Michel Malaise (ORCID: https://orcid.org/0000-0002-0132-2867)
- Monique Henket (ORCID: https://orcid.org/0000-0001-9648-9645)
- Clio Ribbens
- Béatrice André
- Latifa Idoufkir
Institutions
- University of Liège (BE)
- School of the Art Institute of Chicago (US)
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- Centre Hospitalier Universitaire de Liège (BE)
Publication Details
- Journal
- European Respiratory Journal
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1183/13993003.00276-2024
- Citations
- 3
- Primary Topic
- Systemic Sclerosis and Related Diseases
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- Université de Liège
- Servier