TNFAIP2 promotes NF-κB signaling mediate lymph node metastasis of oral squamous cell carcinoma by protecting IKKβ from ubiquitin proteasome degradation
Above results showed TNFAIP2 promoted EMT and lymphangiogenesis of OSCC by regulating NF-κB signaling, a mechanism that was dependent on the interaction with KEAP1 competitively. The nHAp based TNFAIP2 interference might serve as a novel therapeutic in limiting OSCC metastasis.
Authors
- Zechen Zhao
- Yaning Wang
- Qingguo Lai (ORCID: https://orcid.org/0000-0003-4504-5344)
- Jinsong Wang (ORCID: https://orcid.org/0000-0002-3425-7387)
- Xu Teng (ORCID: https://orcid.org/0000-0002-0566-5859)
- Xiaomeng Song (ORCID: https://orcid.org/0000-0001-6844-5936)
- Yuemei Yang (ORCID: https://orcid.org/0000-0002-9095-323X)
- Zhenyuan Zhao (ORCID: https://orcid.org/0009-0004-0560-8549)
Institutions
- Shandong University (CN)
- Wuhan University (CN)
- Shanghai Ninth People's Hospital (CN)
- Second Hospital of Shandong University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1186/s12964-025-02077-3
- Citations
- 9
- Primary Topic
- NF-κB Signaling Pathways
- Type
- article
- Field-Weighted Citation Impact
- 8.43
Funders
- China Postdoctoral Science Foundation
- National Key Research and Development Program of China