Fingolimod Suppresses NLRP3 Inflammasome Activation and Alleviates Oxidative Stress in Traumatic Brain Injury-Induced Acute Lung Injury
These findings suggest that NLRP3 inflammasome activation and oxidative stress are key mediators of TBI-induced ALI. Fingolimod exerts protective effects against this condition by inhibiting NLRP3 inflammasome activation, highlighting its potential as a therapeutic agent for TBI-associated pulmonary complications.
Authors
- Yehong Fang (ORCID: https://orcid.org/0000-0001-9840-2136)
- Xiaoguang Tong (ORCID: https://orcid.org/0000-0002-2892-6222)
- Qiaoli Wu (ORCID: https://orcid.org/0000-0002-0056-7643)
- Weijia Fan (ORCID: https://orcid.org/0009-0002-8173-0760)
- Hua Yan (ORCID: https://orcid.org/0000-0003-3482-0261)
- Tingting Hu (ORCID: https://orcid.org/0009-0004-0879-3882)
- Lixia Xu
- Qi Shi
- Yu Lan
- Jiayuanyuan Fu (ORCID: https://orcid.org/0000-0001-8164-3363)
Institutions
- Tianjin Huanhu Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-02-01
- DOI
- https://doi.org/10.2147/jir.s503428
- Citations
- 3
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 2.42