PLSCR1 suppresses SARS-CoV-2 infection by downregulating cell surface ACE2
Phospholipid scramblase 1 (PLSCR1) has been identified as a critical host restriction factor against SARS-CoV-2 infection. In this study, we demonstrated that PLSCR1 inhibited SARS-CoV-2 entry by downregulating the plasma membrane expression of ACE2, the primary receptor for viral entry. Our findings elucidate a novel host-pathogen interaction that not only deepens our understanding of the innate immune response to SARS-CoV-2 but offers potential strategies for therapeutic interventions against COVID-19.
Authors
- Yujin Shi
- Qi Jiang (ORCID: https://orcid.org/0000-0003-0959-5955)
- Xia Xiao (ORCID: https://orcid.org/0000-0001-9819-5819)
- Xinyi Zhang (ORCID: https://orcid.org/0000-0002-9972-3115)
- Zhuo Zhou (ORCID: https://orcid.org/0000-0001-5862-9854)
- Xiaobo Lei (ORCID: https://orcid.org/0000-0002-3455-6723)
- Ruiyi Ma
- Lan Chen (ORCID: https://orcid.org/0000-0003-4426-9944)
- Jianwei Wang (ORCID: https://orcid.org/0000-0002-1116-4559)
- Wenjing Wang (ORCID: https://orcid.org/0000-0003-4035-8552)
- Xiaojing Dong
- Ruonan Li (ORCID: https://orcid.org/0000-0002-9581-2620)
- Zichun Xiang
- Lili Ren
- Tian Zheng
Institutions
- Pioneer (United States) (US)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University (CN)
- King Center (US)
- Suzhou Institute of Systems Medicine (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Journal of Virology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1128/jvi.02085-24
- Citations
- 4
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- Chinese Academy of Medical Sciences
- Peking Union Medical College
- Foundation for Innovative Research Groups of the National Natural Science Foundation of China