Unveiling the synergistic effect of icariin and azole drugs on Candida albicans
We conclude that icariin may increase the sensitivity of <i>C. albicans</i> to azoles via a cell membrane mediated mechanism, based on our results from FUN-1 microscopy and coincubation with cell wall and cell membrane stressors. Further research is required to explore these effects in clinical isolates, particularly fluconazole-resistant <i>C. albicans</i>, with a view towards the clinical application of icariin as a co-adjuvant in antifungal azole therapy.
Authors
- Marina Pascual-Ortiz (ORCID: https://orcid.org/0000-0003-2035-2487)
- Verónica Veses (ORCID: https://orcid.org/0000-0003-0063-0830)
- Chirag C. Sheth (ORCID: https://orcid.org/0000-0002-8303-0218)
- Alba Martínez
- Barbod Aliaghazadeh
Institutions
- Universidad Cardenal Herrera CEU (ES)
Publication Details
- Journal
- Frontiers in Oral Health
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/froh.2025.1517210
- Citations
- 1
- Primary Topic
- Medicinal Plant Pharmacodynamics Research
- Type
- article
- Field-Weighted Citation Impact
- 1.56