Financial Toxicity and Its Association with the Quality of Life of Greek Patients with Cancer: A Cross-Sectional Study

<b>Background/Objectives</b>: Greek cancer patients deal with high out-of-pocket medical expenses in comparison with the European Union average. All these high costs affect the quality of life of cancer patients, leading to financial toxicity. The purpose of this study is to investigate the association between financial toxicity and quality of life in patients undergoing cancer treatment. <b>Methods</b>: A cross-sectional study was conducted in four hospitals in Greece. The Comprehensive Score for Financial Toxicity (COST) Scale was used for the evaluation of financial toxicity, and the EORTC Core Quality of Life questionnaire (EORTC QLQ-C30) was used for the assessment of quality of life. Quantitative variables were first tested for normality using the Kolmogorov-Smirnov criterion. Spearman correlation coefficients (rho) were used to explore the association of two continuous variables. Multiple linear regression analysis was used with dependent the QoL subscales. Logarithmic transformations of the QoL scales were used for the regression analyses. Internal consistency reliability was determined by the calculation of Cronbach's α coefficient. All reported <i>p</i> values are two-tailed. Statistical significance was set at <i>p</i> < 0.05 and analyses were conducted using SPSS statistical software (version 27.0). <b>Results</b>: Greater financial toxicity score, i.e., lower toxicity, was significantly associated with greater global health status (rho = 0.34; <i>p</i> < 0.001) and greater physical (rho = 0.37; <i>p</i> < 0.001), role (rho = 0.17; <i>p</i> = 0.001), emotional (rho = 0.34; <i>p</i> < 0.001), cognitive (rho = 0.22; <i>p</i> < 0.001), and social (rho = 0.27; <i>p</i> < 0.001) functioning. <b>Conclusions</b>: There is a strong correlation between a greater financial toxicity score and the quality of life of Greek cancer patients, meaning the lower their financial toxicity, the better their quality of life.