REPRINTED WITH PERMISSION OF EFIC EJP: 28 (2024): 359–368: Opioid dose titration for cancer pain

<br><b>Background:</b> Opioid dose titration is a fundamental process of opioid therapy in cancer pain.</br><br><b>Aims:</b> To assess data opioid dose titration.</br><br><b>Methods:</b> The principal opioid dose titration methods, outcomes, and modalities of administration regarding the different opioid preparations were examined in different clinical contexts.</br><br><b>Results:</b> Most studies suggested that opioid-naive patients should be started at doses of 15–30 mg/day of oral morphine equivalents. Opioid-tolerant patients may receive low or higher doses of oral morphine equivalents, depending on the level of opioid tolerance. Generally, dose increments of 30–50% seem to be indicated to start dose titration. Some patients with severe excruciating cancer pain may present as an emergency requiring a rapid application of powerful analgesic strategies. The intravenous use of opioids may circumvent this problem providing a faster pain relief, due to the large availability and rapid achievement of effective plasma concentrations.Discussion: Opioid dose titration is a delicate passage in patients with cancer pain. This approach may be different according to different clinical conditions. Opioid dose titration requires expertise to optimize cancer pain management while minimizing the development of adverse effects.</br><br><b>Conclusions:</b> While most approaches are meaningful and partially supported by existing literature, more studies are necessary to establish advantages and disadvantages in different clinical conditions. Optimization of opioid dose titration is of paramount importance.</br><br><b>Significance:</b> This review provides the most recent insights on the different modalities of opioid dose titration in cancer pain management.</br>