First Clade Ib Monkeypox Virus Infection Reported in the Americas — California, November 2024

A clade I monkeypox virus (MPXV) outbreak is ongoing in the Democratic Republic of the Congo; travel-associated clade I MPXV infections have been reported in non-African countries. In November 2024, San Mateo County Health in California identified an electronic laboratory report of polymerase chain reaction results suggestive of clade I MPXV infection in a male traveler who had recently returned from East Africa. After conferring with the California Department of Public Health (CDPH), a county health department worker visited the patient that same day at his home and obtained skin pustule swab specimens for expedited clade I MPXV testing. Clade I MPXV was confirmed the following day by the CDPH Viral and Rickettsial Disease Laboratory. This was the first reported clade I MPXV infection in the Americas. Among 83 identified contacts, five received JYNNEOS vaccine as postexposure prophylaxis. All contacts were monitored for 21 days; no secondary cases were identified. Patients with mpox-compatible lesions or clinical features should receive MPXV testing, and health care providers should immediately notify public health authorities of suspected clade I MPXV infections (e.g., mpox manifestations and travel history to an area with ongoing clade I MPXV transmission) or upon receiving a nonvariola orthopoxvirus DNA detected, clade II MPXV DNA undetectable test result to trigger additional testing and facilitate the rapid implementation of transmission-based precautions and other preventive public health interventions.

Authors

Publication Details

Journal
MMWR Morbidity and Mortality Weekly Report
Published
2025-02-13
DOI
https://doi.org/10.15585/mmwr.mm7404a1
Citations
10
Primary Topic
Poxvirus research and outbreaks
Type
article
Field-Weighted Citation Impact
10.36

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article

First Clade Ib Monkeypox Virus Infection Reported in the Americas — California, November 2024

Kelly A. Johnson, Alida M. Gertz, Bárbara Silva Gonzaga, Shama Cash‐Goldwasser et al.
10 citations
MMWR Morbidity and Mortality Weekly Report
Poxvirus research and outbreaks
10.36
article

First Clade Ib Monkeypox Virus Infection Reported in the Americas — California, November 2024

Kelly A. Johnson, Alida M. Gertz, Bárbara Silva Gonzaga, Shama Cash‐Goldwasser, Robert E. Snyder, Ermias D. Belay, Rachael Piper, Aaron Kofman, Alyssa Newman, Dominique Lemoine, Faisal S. Minhaj, Monica Haw, Juliet Stoltey, Agam K. Rao, R. Ryan Lash, Andrea M. McCollum, Shannon Gearhart, Jill K. Hacker, Ian Williams, Emily Sims, Marie De Perio, Erin Epson, Alexander Kallen, A. D. McNaghten, Shiffen Getabecha, Eric C. Tang, Robert M. Avina, Christina L. Hutson, María Salas, Panayampalli S. Satheshkumar, Chantha Kath, Ricardo Berumen, Vivian Wong, Kristina Hsieh, Alex Espinosa, Jiusheng Deng, Jessica Watson, Kayla Saadeh, Debra A. Wadford, Awa Keinde, Edwin Chojolan, Italo Zecca, David W. Hunter, Whitni Davidson, Vivian Levy, Crystal M. Gigante, Will Probert, Kathleen M. Jacobson, Rilene A. Chew Ng, Daniel S. Dodson, Anna Branzuela, Josh Bunao, Jahara Cayabyab, Kelsey Maccuish, Alexia McGonagle, Brandon Stavig, Orlanda Tafolla, Gillian Marek
article en
10 citations

Abstract

A clade I monkeypox virus (MPXV) outbreak is ongoing in the Democratic Republic of the Congo; travel-associated clade I MPXV infections have been reported in non-African countries. In November 2024, San Mateo County Health in California identified an electronic laboratory report of polymerase chain reaction results suggestive of clade I MPXV infection in a male traveler who had recently returned from East Africa. After conferring with the California Department of Public Health (CDPH), a county health department worker visited the patient that same day at his home and obtained skin pustule swab specimens for expedited clade I MPXV testing. Clade I MPXV was confirmed the following day by the CDPH Viral and Rickettsial Disease Laboratory. This was the first reported clade I MPXV infection in the Americas. Among 83 identified contacts, five received JYNNEOS vaccine as postexposure prophylaxis. All contacts were monitored for 21 days; no secondary cases were identified. Patients with mpox-compatible lesions or clinical features should receive MPXV testing, and health care providers should immediately notify public health authorities of suspected clade I MPXV infections (e.g., mpox manifestations and travel history to an area with ongoing clade I MPXV transmission) or upon receiving a nonvariola orthopoxvirus DNA detected, clade II MPXV DNA undetectable test result to trigger additional testing and facilitate the rapid implementation of transmission-based precautions and other preventive public health interventions.

MMWR Morbidity and Mortality Weekly ReportVol. 74(4)
California Department of Public Health, Centers for Disease Control and Prevention
Openalex Percentile: Top 1%
Poxvirus research and outbreaks
10.36
DOIOpen Access PDFOpenAlex
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