Effective Treatment of Disseminated Prostate Cancer Using CD46-Targeted 225Ac Therapy
Our findings highlight that [225Ac]Macropa-PEG4-YS5 holds the potential for clinical translation for metastatic prostate cancer and reinforces the value of microdosimetry in understanding the efficacy of and resistance to targeted alpha therapy. See related commentary by Patel et al., p. 2847.
Authors
- Shubhankar Naik (ORCID: https://orcid.org/0000-0002-9640-1188)
- Robin Peter (ORCID: https://orcid.org/0009-0003-3448-8462)
- Renuka Sriram (ORCID: https://orcid.org/0000-0003-3505-2479)
- Nancy Greenland (ORCID: https://orcid.org/0000-0002-1783-1711)
- Anju Wadhwa (ORCID: https://orcid.org/0009-0006-0826-8134)
- Adam Oskowitz (ORCID: https://orcid.org/0000-0002-7213-0555)
- Jiang He (ORCID: https://orcid.org/0000-0001-7600-4604)
- Anil P. Bidkar (ORCID: https://orcid.org/0000-0003-1249-1081)
- Jonathan Chou (ORCID: https://orcid.org/0000-0003-1258-0391)
- David M. Wilson (ORCID: https://orcid.org/0000-0002-1095-046X)
- Veronica Steri (ORCID: https://orcid.org/0000-0003-2499-6618)
- Bin Liu (ORCID: https://orcid.org/0000-0001-9137-5067)
- Scott C. Kogan (ORCID: https://orcid.org/0000-0002-2395-8479)
- Scott Bidlingmaier (ORCID: https://orcid.org/0000-0003-4955-9713)
- Kondapa Naidu Bobba (ORCID: https://orcid.org/0000-0001-6304-2855)
- Megha Basak (ORCID: https://orcid.org/0000-0002-2422-184X)
- Chandrashekhar Dasari (ORCID: https://orcid.org/0000-0002-7526-2190)
- Niranjan Meher (ORCID: https://orcid.org/0000-0003-3558-3712)
- Athira Raveendran (ORCID: https://orcid.org/0000-0002-4853-4330)
- Juan A. Cámara (ORCID: https://orcid.org/0000-0001-7494-1127)
- Henry F. VanBrocklin (ORCID: https://orcid.org/0000-0003-2849-0841)
- Youngho Seo (ORCID: https://orcid.org/0000-0001-5908-6636)
- Rahul Aggarwal (ORCID: https://orcid.org/0000-0001-7003-7982)
- Robert R. Flavell (ORCID: https://orcid.org/0000-0002-8694-1199)
Institutions
- University of California, San Francisco (US)
- Central Drug Research Institute (IN)
- National Institute of Pharmaceutical Education and Research - Ahmedabad (IN)
- University of Virginia Medical Center (US)
- UCSF Helen Diller Family Comprehensive Cancer Center (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1158/1078-0432.ccr-24-2850
- Citations
- 8
- Primary Topic
- Radiopharmaceutical Chemistry and Applications
- Type
- article
- Field-Weighted Citation Impact
- 10.88
Funders
- U.S. Department of Defense
- National Cancer Institute
- National Institute of Biomedical Imaging and Bioengineering
- DOD Prostate Cancer Research Program