The Germline and Somatic Origins of Prostate Cancer Heterogeneity
This study uncovered 223 recurrently mutated driver regions using the largest cohort of prostate tumors to date. It reveals associations between germline SNPs, somatic drivers, and tumor aggression, offering significant insights into how prostate tumor evolution is shaped by germline factors and the timing of somatic mutations.
Authors
- Matthew J. Wakefield (ORCID: https://orcid.org/0000-0001-6624-4698)
- Christopher M. Lalansingh (ORCID: https://orcid.org/0000-0003-1225-0931)
- Shingai B.A. Mutambirwa (ORCID: https://orcid.org/0000-0003-1414-0218)
- Phillip D. Stricker (ORCID: https://orcid.org/0000-0002-0934-0656)
- Paul C. Boutros (ORCID: https://orcid.org/0000-0003-0553-7520)
- Michael Kerger (ORCID: https://orcid.org/0000-0002-9745-728X)
- Mark M. Pomerantz
- Eva K.F. Chan (ORCID: https://orcid.org/0000-0002-6104-3763)
- Ji-Heui Seo (ORCID: https://orcid.org/0000-0002-7280-3334)
- Riana Bornman (ORCID: https://orcid.org/0000-0003-3975-2333)
- Robert Glen Bristow (ORCID: https://orcid.org/0000-0002-8553-9544)
- Andrew Lonie (ORCID: https://orcid.org/0000-0002-2006-3856)
- Jue Jiang (ORCID: https://orcid.org/0000-0003-0920-8310)
- Marek Cmero (ORCID: https://orcid.org/0000-0001-7783-5530)
- Bernard Têtu (ORCID: https://orcid.org/0000-0003-2771-2641)
- Job van Riet (ORCID: https://orcid.org/0000-0001-7767-7923)
- Ram S. Mani (ORCID: https://orcid.org/0000-0003-3552-7905)
- Ken Chow (ORCID: https://orcid.org/0000-0001-5904-2684)
- Lachlan McIntosh (ORCID: https://orcid.org/0009-0005-3543-0259)
- Takafumi N. Yamaguchi (ORCID: https://orcid.org/0000-0003-1082-3871)
- Anne Nguyen
- Vanessa M. Hayes (ORCID: https://orcid.org/0000-0002-4524-7280)
- Connor Bell (ORCID: https://orcid.org/0000-0002-2148-2972)
- Ryan Stuchbery (ORCID: https://orcid.org/0000-0003-3670-2023)
- Hélène Hovington (ORCID: https://orcid.org/0000-0002-5500-5648)
- Adrien Foucal (ORCID: https://orcid.org/0000-0003-1619-0753)
- Richard Jovelin (ORCID: https://orcid.org/0009-0006-7656-8438)
- Anthony J. Costello (ORCID: https://orcid.org/0000-0003-3083-1799)
- Veronica Y. Sabelnykova
- Susmita G. Ramanand (ORCID: https://orcid.org/0000-0001-9711-0342)
- Natalie J. Kurganovs (ORCID: https://orcid.org/0000-0002-8555-5528)
- Alexander Gusev (ORCID: https://orcid.org/0000-0002-7980-4620)
- Joachim Weischenfeldt (ORCID: https://orcid.org/0000-0002-3917-5524)
- Valérie Picard (ORCID: https://orcid.org/0000-0002-8414-863X)
- Alain Bergeron (ORCID: https://orcid.org/0000-0002-2875-0773)
- Vincent Huang (ORCID: https://orcid.org/0000-0002-6504-179X)
- Weerachai Jaratlerdsiri (ORCID: https://orcid.org/0000-0001-9100-1807)
- John D. McPherson (ORCID: https://orcid.org/0000-0001-8049-9347)
- Shadrielle M. G. Espiritu
- Sebastian M. Waszak (ORCID: https://orcid.org/0000-0003-3042-9521)
- Housheng Hansen He (ORCID: https://orcid.org/0000-0003-2898-3363)
- Patrick J. McCoy (ORCID: https://orcid.org/0000-0001-9412-110X)
- Lawrence E. Heisler (ORCID: https://orcid.org/0000-0002-1332-1802)
- Rayjean J. Hung (ORCID: https://orcid.org/0000-0002-4486-7496)
- Anthony T. Papenfuss (ORCID: https://orcid.org/0000-0002-1102-8506)
- Daniel J. Park (ORCID: https://orcid.org/0000-0002-6354-0931)
- Bernard J. Pope (ORCID: https://orcid.org/0000-0002-4840-1095)
- Chol-Hee Jung (ORCID: https://orcid.org/0000-0002-2992-3162)
- Theodorus van der Kwast (ORCID: https://orcid.org/0000-0001-8640-5786)
- Bogdan Paşaniuc (ORCID: https://orcid.org/0000-0002-0227-2056)
- Noah Zaitlen (ORCID: https://orcid.org/0000-0002-3553-3670)
- Julie Livingstone (ORCID: https://orcid.org/0000-0002-8424-3768)
- Dorota H.S. Sendorek (ORCID: https://orcid.org/0000-0001-6199-246X)
- Michèle Orain (ORCID: https://orcid.org/0000-0002-9779-1851)
- Stefano Mangiola (ORCID: https://orcid.org/0000-0001-7474-836X)
- Andrew Ryan (ORCID: https://orcid.org/0000-0002-5337-4714)
- Jocelyn Sietsma Penington (ORCID: https://orcid.org/0000-0003-1561-0074)
- Robert Lesurf (ORCID: https://orcid.org/0000-0001-7095-1491)
- Yves Fradet (ORCID: https://orcid.org/0000-0002-7581-2500)
- Kodi Taraszka (ORCID: https://orcid.org/0000-0002-1921-2113)
- Amar U. Kishan (ORCID: https://orcid.org/0000-0002-4836-8483)
- Stephenie D. Prokopec (ORCID: https://orcid.org/0000-0001-7936-8577)
- Martijn P. Lolkema (ORCID: https://orcid.org/0000-0003-0466-2928)
- Christopher M. Hovens (ORCID: https://orcid.org/0000-0002-0610-1289)
- Jiapei Yuan (ORCID: https://orcid.org/0000-0002-9381-8623)
- Michael Fraser (ORCID: https://orcid.org/0000-0002-9303-9363)
- Vinayak Bhandari (ORCID: https://orcid.org/0000-0003-0265-0835)
- Peter Georgeson (ORCID: https://orcid.org/0000-0002-5096-4735)
- Matthew L. Freedman (ORCID: https://orcid.org/0000-0002-0151-1238)
- Kathleen E. Houlahan (ORCID: https://orcid.org/0000-0002-2273-2099)
- Lydia Liu (ORCID: https://orcid.org/0000-0001-6026-3169)
- Jüri Reimand (ORCID: https://orcid.org/0000-0002-2299-2309)
- Tommer Schwarz (ORCID: https://orcid.org/0000-0003-1777-3280)
- Louis Lacombe (ORCID: https://orcid.org/0000-0003-4811-0308)
- Niall M. Corcoran (ORCID: https://orcid.org/0000-0003-4483-6945)
- Helen Zhu (ORCID: https://orcid.org/0000-0002-5174-4582)
- Yu-Jia Shiah
- Adriana Salcedo (ORCID: https://orcid.org/0000-0002-3365-2705)
- Edward O’Connor (ORCID: https://orcid.org/0000-0003-3758-8576)
- Michael J. Clarkson (ORCID: https://orcid.org/0009-0001-8586-0338)
- Justin S. Peters
- Natalie S. Fox
Institutions
- Ontario Institute for Cancer Research (CA)
- University of Copenhagen (DK)
- Oslo University Hospital (NO)
- Brigham and Women's Hospital (US)
- Prostate Cancer Foundation of Australia (AU)
- The University of Sydney (AU)
- The Royal Melbourne Hospital (AU)
- University Health Network (CA)
- Garvan Institute of Medical Research (AU)
- University of California, Los Angeles (US)
- The University of Melbourne (AU)
- University of Toronto (CA)
- Walter and Eliza Hall Institute of Medical Research (AU)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Lunenfeld-Tanenbaum Research Institute (CA)
- Peter MacCallum Cancer Centre (AU)
- Erasmus MC (NL)
- Sefako Makgatho Health Sciences University (ZA)
- Princess Margaret Cancer Centre (CA)
- Rigshospitalet (DK)
- Melbourne Bioinformatics (AU)
- St Vincent's Hospital Sydney (AU)
- Cooperative Trials Group for Neuro-Oncology (AU)
- Southwestern Medical Center (US)
- Center for Personalized Cancer Treatment (NL)
- Victorian Comprehensive Cancer Centre (AU)
- Prostate Cancer Research (GB)
- Dana-Farber Cancer Institute (US)
- Peninsula Health (AU)
- Monash Health (AU)
- St Vincent's Clinic (AU)
- Public Health Ontario (CA)
- Vector Institute (CA)
- Cancer Research UK Manchester Institute (GB)
- Eli and Edythe Broad Foundation (US)
- Centre hospitalier de l'Université Laval (CA)
- Institute of Hematology & Blood Diseases Hospital (CN)
- TissuPath (AU)
- Université Laval (CA)
- École Polytechnique Fédérale de Lausanne (CH)
- Monash University (AU)
- University of Pretoria (ZA)
- Oklahoma State University Center for Health Sciences (US)
- Charité - Universitätsmedizin Berlin (DE)
- Neuroscience Research Australia (AU)
- The University of Texas Southwestern Medical Center (US)
- University of Limpopo (ZA)
- Erasmus University Rotterdam (NL)
- Stanford University (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1158/2159-8290.cd-23-0882
- Citations
- 10
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 15.18
Funders
- National Cancer Institute
- DOD Prostate Cancer Research Program