Memory CD4+ T cells sequentially restructure their 3D genome during stepwise activation
This suggests a stepwise process whereby mCD4+ T cells undergo sequential buildup of 3D architecture induced by distinct or combined stimuli likely to "prime" or "deprime" them for expression responses to subsequent TCR-antigen ligation or additional cytokine stimulation.
Authors
- Jose I. de las Heras (ORCID: https://orcid.org/0000-0002-3872-3015)
- Ariberto Fassati (ORCID: https://orcid.org/0000-0003-1934-5327)
- Eric C. Schirmer (ORCID: https://orcid.org/0000-0003-2635-1338)
- Alexander I. Ward
Institutions
- University College London (GB)
- University of Edinburgh (GB)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fcell.2025.1514627
- Citations
- 1
- Primary Topic
- T-cell and B-cell Immunology
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- Medical Research Council