Extracorporeal photopheresis induces the release of anti-inflammatory fatty acids and oxylipins and suppresses pro-inflammatory sphingosine-1-phosphate

In conclusion, we suggest that the ECP-induced changes in lipid mediators may contribute to the remarkable anti-inflammatory effects of the treatment. Depending on their lipid status, patients may benefit from novel treatment regimens combining ECP with lipid modulators. This could be used for the prevention of transplant organ rejection, the treatment of acute or chronic GvHD or transplant organ rejection and the long-term treatment of various skin diseases. This study uncovers novel mechanisms of ECP, that can be used to establish clinically relevant lipid profiles of patients to support patient stratification, predictive or prognostic purposes and thus personalized medical care in the framework of PPPM practice. A combination with S1P modulators may therefore have beneficial effects.

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Publication Details

Journal
Inflammation Research
Published
2025-02-13
DOI
https://doi.org/10.1007/s00011-025-02007-6
Citations
1
Primary Topic
Hematopoietic Stem Cell Transplantation
Type
article
Field-Weighted Citation Impact
1.77

Funders

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article

Extracorporeal photopheresis induces the release of anti-inflammatory fatty acids and oxylipins and suppresses pro-inflammatory sphingosine-1-phosphate

Nina Zila, Thomas Mohr, Gerhard Hagn, Michael J. Koren et al.
1 citations
Inflammation Research
Hematopoietic Stem Cell Transplantation
1.77
article

Extracorporeal photopheresis induces the release of anti-inflammatory fatty acids and oxylipins and suppresses pro-inflammatory sphingosine-1-phosphate

Nina Zila, Thomas Mohr, Gerhard Hagn, Michael J. Koren, A. Cho, Christopher Gerner, Dexin Dong, Barbara Sterniczky, Philipp Paulitschke, Christian Jantschitsch, Wolfgang Weninger, Andrea Bileck, Verena Paulitschke, Robert Knobler
article en
1 citations

Abstract

In conclusion, we suggest that the ECP-induced changes in lipid mediators may contribute to the remarkable anti-inflammatory effects of the treatment. Depending on their lipid status, patients may benefit from novel treatment regimens combining ECP with lipid modulators. This could be used for the prevention of transplant organ rejection, the treatment of acute or chronic GvHD or transplant organ rejection and the long-term treatment of various skin diseases. This study uncovers novel mechanisms of ECP, that can be used to establish clinically relevant lipid profiles of patients to support patient stratification, predictive or prognostic purposes and thus personalized medical care in the framework of PPPM practice. A combination with S1P modulators may therefore have beneficial effects.

Inflammation ResearchVol. 74(1)
University of Vienna (AT), Hochschule Campus Wien (AT), Medical University of Vienna (AT)
Universität Wien, Medizinische Universität Wien
Good health and well-being
Openalex Percentile: Top 19%
Hematopoietic Stem Cell Transplantation
1.77
DOIOpen Access PDFOpenAlex
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