Effect of Dync1h1 on Phototransduction Protein Transport and the Development and Maintenance of Photoreceptor Cells in Zebrafish
Dync1h1 is essential for maintaining retrograde axonal transport and proper trafficking of phototransduction proteins in PRCs. Non-resolving ER stress-induced PRC apoptosis is a key factor in DYNC1H1-associated retinal degeneration. This study provides important insights into the precise diagnosis and may help in the development of targeted therapies for retinal degenerative diseases.
Authors
- Wanqing Tong
- Jianan Xie (ORCID: https://orcid.org/0000-0001-9084-8272)
- Bo Jia (ORCID: https://orcid.org/0000-0002-9827-9331)
- Xuebin Zhou (ORCID: https://orcid.org/0000-0002-0715-9829)
- Jinfeng Cao (ORCID: https://orcid.org/0000-0001-8826-311X)
- Jinling Fu
Institutions
- Second Affiliated Hospital of Jilin University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1167/iovs.66.2.38
- Citations
- 2
- Primary Topic
- Retinal Development and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.61