Targeting Runx1 in Pathological Retinal Angiogenesis: A Potential Therapeutic Approach
Runx1 is essential for physiological retinal vascularization. RUNX1 Inhibition may effectively decrease pathological neovascularization. Our findings suggest that targeting RUNX1 could be a promising therapeutic strategy for retinal neovascular disorders, preserving the integrity of mature blood vessels while selectively inhibiting neovascularization.
Authors
- Wenjia Yan (ORCID: https://orcid.org/0000-0001-6708-2520)
- Aohan Hou
- Xiaoyan Ding (ORCID: https://orcid.org/0000-0003-4936-3315)
- Xiaodi Zhou
- Yizhe Cheng (ORCID: https://orcid.org/0000-0002-9619-748X)
- Limei Sun
- Li-Mei Chen (ORCID: https://orcid.org/0000-0001-9589-9474)
- Yanting Lai
- Xinyu Liu (ORCID: https://orcid.org/0009-0002-1674-1500)
Institutions
- Sun Yat-sen University (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1167/iovs.66.2.40
- Citations
- 2
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.41
Funders
- National Natural Science Foundation of China
- Sun Yat-sen University
- State Key Laboratory of Ophthalmology