Metastatic Gestational Trophoblastic Neoplasia Leading to Acute Respiratory Failure and Death: A Case Report – About a Particularly Challenging Management in the Intensive Care Unit, and Exploring the Potential of Pembrolizumab in Treating Frail, Pre

This case underscores the importance of prompt recognition and timely intervention in the management of patients with ARDS during the early postpartum period. GTN with lung involvement should be considered after excluding the other more frequent causes of ARDS. It also highlights how ECMO support enables the continuation of chemotherapy and the achievement of remission in CC. Furthermore, due to the inability to initiate the desired chemotherapy, immunotherapy was introduced as a possible treatment modality. Therefore, this case underscores the importance of adaptability in treatment plans based on patient-specific clinical conditions and collaborative decision-making with specialized centers. Finally, it emphasizes the efficacy of pembrolizumab, even as a monotherapy, in pretreated CC cases.

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Publication Details

Journal
Case Reports in Oncology
Published
2025-02-13
DOI
https://doi.org/10.1159/000543518
Citations
3
Primary Topic
Gestational Trophoblastic Disease Studies
Type
article
Field-Weighted Citation Impact
5.64
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article

Metastatic Gestational Trophoblastic Neoplasia Leading to Acute Respiratory Failure and Death: A Case Report – About a Particularly Challenging Management in the Intensive Care Unit, and Exploring the Potential of Pembrolizumab in Treating Frail, Pre

Laura Polastro, Ahmad Awada, Frédéric Goffin, J. Chaves et al.
3 citations
Case Reports in Oncology
Gestational Trophoblastic Disease Studies
5.64
article

Metastatic Gestational Trophoblastic Neoplasia Leading to Acute Respiratory Failure and Death: A Case Report – About a Particularly Challenging Management in the Intensive Care Unit, and Exploring the Potential of Pembrolizumab in Treating Frail, Pre

Laura Polastro, Ahmad Awada, Frédéric Goffin, J. Chaves, Katarina Halenarova, Aspasia Georgala, Maxime Fastrez, Jacques Devière, Maxime Ilzkovitz, Martina Pezzullo, M. A. Meyers, Marine Najmaoui
article en
3 citations

Abstract

This case underscores the importance of prompt recognition and timely intervention in the management of patients with ARDS during the early postpartum period. GTN with lung involvement should be considered after excluding the other more frequent causes of ARDS. It also highlights how ECMO support enables the continuation of chemotherapy and the achievement of remission in CC. Furthermore, due to the inability to initiate the desired chemotherapy, immunotherapy was introduced as a possible treatment modality. Therefore, this case underscores the importance of adaptability in treatment plans based on patient-specific clinical conditions and collaborative decision-making with specialized centers. Finally, it emphasizes the efficacy of pembrolizumab, even as a monotherapy, in pretreated CC cases.

Case Reports in OncologyVol. 18(1)
Institut Jules Bordet (BE), Erasmus Hospital (BE), Joint Research Center (BE), Centre Hospitalier Universitaire de Liège (BE)
Good health and well-being
Openalex Percentile: Top 5%
Gestational Trophoblastic Disease Studies
5.64
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