Metastatic Gestational Trophoblastic Neoplasia Leading to Acute Respiratory Failure and Death: A Case Report – About a Particularly Challenging Management in the Intensive Care Unit, and Exploring the Potential of Pembrolizumab in Treating Frail, Pre
This case underscores the importance of prompt recognition and timely intervention in the management of patients with ARDS during the early postpartum period. GTN with lung involvement should be considered after excluding the other more frequent causes of ARDS. It also highlights how ECMO support enables the continuation of chemotherapy and the achievement of remission in CC. Furthermore, due to the inability to initiate the desired chemotherapy, immunotherapy was introduced as a possible treatment modality. Therefore, this case underscores the importance of adaptability in treatment plans based on patient-specific clinical conditions and collaborative decision-making with specialized centers. Finally, it emphasizes the efficacy of pembrolizumab, even as a monotherapy, in pretreated CC cases.
Authors
- Laura Polastro (ORCID: https://orcid.org/0000-0003-1196-5118)
- Ahmad Awada (ORCID: https://orcid.org/0000-0001-7412-9163)
- Frédéric Goffin (ORCID: https://orcid.org/0000-0001-9327-9204)
- J. Chaves (ORCID: https://orcid.org/0009-0009-4844-7323)
- Katarina Halenarova (ORCID: https://orcid.org/0000-0002-5641-825X)
- Aspasia Georgala (ORCID: https://orcid.org/0000-0003-0286-864X)
- Maxime Fastrez (ORCID: https://orcid.org/0000-0001-7466-1205)
- Jacques Devière (ORCID: https://orcid.org/0000-0002-7993-1945)
- Maxime Ilzkovitz (ORCID: https://orcid.org/0000-0003-2216-3495)
- Martina Pezzullo
- M. A. Meyers (ORCID: https://orcid.org/0000-0003-4150-4240)
- Marine Najmaoui
Institutions
- Institut Jules Bordet (BE)
- Erasmus Hospital (BE)
- Joint Research Center (BE)
- Centre Hospitalier Universitaire de Liège (BE)
Publication Details
- Journal
- Case Reports in Oncology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1159/000543518
- Citations
- 3
- Primary Topic
- Gestational Trophoblastic Disease Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.64