Synchronous Double Primary Malignancy of Non-Small Cell Lung Cancer and Glioblastoma: A Case Report and Literature Review

Herein is the third report regarding synchronous double primary malignancies involving non-small cell lung cancer (NSCLC) and GB. This report of an assumed metastatic NSCLC patient with a solitary brain lesion, history of smoking, and COPD underscores the need for pathological confirmation of all new presentations of metastatic disease via biopsy and highlights the importance of including the possibility of a second primary in the differential diagnosis. Additional reports of NSCLC and synchronous solitary brain lesions are needed to further elucidate pertinent patient characteristics and better inform clinical decision making.