Differential association of selenium exposure with insulin resistance and β-cell function in middle age and older adults
Increased blood selenium was associated with increased insulin resistance and β-cell function in middle-aged, but not in older individuals, especially for β-cell function. The results suggest that selenium-associated insulin resistance might induce compensatory increased β-cell function at younger ages, being this compensatory capacity decreased with aging.
Authors
- María Grau-Pérez (ORCID: https://orcid.org/0000-0003-1660-9972)
- Josep Redón (ORCID: https://orcid.org/0000-0001-8777-6773)
- José Puzo (ORCID: https://orcid.org/0000-0002-1309-4363)
- Belén Moreno‐Franco (ORCID: https://orcid.org/0000-0003-0604-5042)
- Fernando Gil (ORCID: https://orcid.org/0000-0001-9816-8618)
- José Luis Gómez‐Ariza (ORCID: https://orcid.org/0000-0001-7997-7444)
- Fernando Rodríguez‐Artalejo (ORCID: https://orcid.org/0000-0001-9317-5755)
- María Téllez-Plaza (ORCID: https://orcid.org/0000-0002-3850-1228)
- Mercedes Sotos‐Prieto (ORCID: https://orcid.org/0000-0001-9127-2586)
- Zulema Rodriguez-Hernandez (ORCID: https://orcid.org/0000-0003-0720-384X)
- José A. Casasnovas (ORCID: https://orcid.org/0000-0002-9887-2629)
- Roberto Pastor‐Barriuso (ORCID: https://orcid.org/0000-0002-7325-3960)
- Rosario Ortolá (ORCID: https://orcid.org/0000-0001-6952-9533)
- Esther García‐Esquinas (ORCID: https://orcid.org/0000-0002-8688-5174)
- Martín Laclaustra (ORCID: https://orcid.org/0000-0003-3963-0846)
- Ana Cenarro
- Pablo Olmedo (ORCID: https://orcid.org/0000-0001-5022-6495)
- Tamara García‐Barrera (ORCID: https://orcid.org/0000-0002-8859-9550)
- Fernando Civeira (ORCID: https://orcid.org/0000-0001-7043-0952)
- José R. Banegas (ORCID: https://orcid.org/0000-0001-6152-9862)
- Javier Bel-Aguilar
Institutions
- Madrid Institute for Advanced Studies (ES)
- Harvard University (US)
- Universitat de València (ES)
- University of Freiburg (DE)
- Universidad de Granada (ES)
- Universidad de Zaragoza (ES)
- University Medical Center Freiburg (DE)
- Instituto de Salud Carlos III (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Hospital Universitario Miguel Servet (ES)
- Instituto de Investigación Sanitaria Aragón (ES)
- IMDEA Food (ES)
- Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (ES)
- INCLIVA Health Research Institute (ES)
- Universitat Politècnica de València (ES)
- Universidad Autónoma de Madrid (ES)
- Universidad de Huelva (ES)
Publication Details
- Journal
- Nutrition and Diabetes
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1038/s41387-025-00361-2
- Citations
- 4
- Primary Topic
- Selenium in Biological Systems
- Type
- article
- Field-Weighted Citation Impact
- 4.48
Funders
- European Commission
- Deutsche Forschungsgemeinschaft
- Centro para el Desarrollo Tecnológico Industrial
- Ministerio de Economía y Competitividad
- Gobierno de Aragón
- Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación