Relationship Between Growth Differentiation Factor-15 and Global Registry of Acute Coronary Events Score in Patients with Non-St Segment Elevation Acute Coronary Syndrome

Introduction: One of the main causes of hospitalization and death is NSTE-ACS. A GRACE risk score tool specifically designed for risk stratification of acute coronary syndrome patients is needed. The GRACE score has limitations related to the uncertainty of atherosclerotic plaque rupture and difficulty in predicting. GDF-15 is one possibility that is necessary because the results depend on an assessment of risk at a point in time. Elevated circulating levels of GDF-15 are associated with poor prognosis in many acute and chronic conditions including heart disease. Research linking GDF-15 with GRACE scores is limited and requires further study. analyze the relationship between GDF-15 and GRACE Score in NSTE-ACS patients. Methods: Analytical observational study with a cross-sectional method, 37 subjects were taken at Airlangga University Hospital in july-November 2024. GDF-15 levels were measured using the ELISA method using a Bio-rad reader. Analysis used the SPSS 25 series Spearman test. Results: subjects (n=40) were predominantly aged 60.98±8,592, 70% male, and 67.5% had a history of hypertension. The median GDF-15 level was 574.53 with a minimum level of 77 ng/L and a maximum of 2913 ng/L, the mean GRACE score was 95.65±18.307 with the highest score of 147. Statistical analysis showed a strong relationship between GDF-15 and the GRACE (contingency coefficient 0.724 with p 0.001). Conclusions: GDF-15 can be used as an alternative additional marker in GRACE score assessment.