Allogeneic Chimeric Antigen Receptor T-Cell Products Cemacabtagene Ansegedleucel/ALLO-501 in Relapsed/Refractory Large B-Cell Lymphoma: Phase I Experience From the ALPHA2/ALPHA Clinical Studies

Allogeneic CD19 CAR T cells demonstrated promising overall and durable CR rates with a manageable safety profile in CD19 CAR T-naïve patients with R/R LBCL, supporting additional evaluation of cema-cel in patients with LBCL.

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Publication Details

Journal
Journal of Clinical Oncology
Published
2025-02-13
DOI
https://doi.org/10.1200/jco-24-01933
Citations
27
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
28.23
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article

Allogeneic Chimeric Antigen Receptor T-Cell Products Cemacabtagene Ansegedleucel/ALLO-501 in Relapsed/Refractory Large B-Cell Lymphoma: Phase I Experience From the ALPHA2/ALPHA Clinical Studies

Mehdi Hamadani, Geoffrey Shouse, Frederick Lundry Locke, John B. Le Gall et al.
27 citations
Journal of Clinical Oncology
CAR-T cell therapy research
28.23
article

Allogeneic Chimeric Antigen Receptor T-Cell Products Cemacabtagene Ansegedleucel/ALLO-501 in Relapsed/Refractory Large B-Cell Lymphoma: Phase I Experience From the ALPHA2/ALPHA Clinical Studies

Mehdi Hamadani, Geoffrey Shouse, Frederick Lundry Locke, John B. Le Gall, Don A. Stevens, Olalekan O. Oluwole, Lynn Navale, Michael Tees, Sattva Swarup Neelapu, Lazaros J. Lekakis, Sven de Vos, David B. Miklos, Miguel‐Angel Perales, Javier Muñoz, Shahbaz A. Malik, Rajneesh Nath, P.W. Fisher, Amy Feng
article en
27 citations

Abstract

Allogeneic CD19 CAR T cells demonstrated promising overall and durable CR rates with a manageable safety profile in CD19 CAR T-naïve patients with R/R LBCL, supporting additional evaluation of cema-cel in patients with LBCL.

Journal of Clinical OncologyVol. 43(14)
City Of Hope National Medical Center (US), Memorial Sloan Kettering Cancer Center (US), The University of Texas MD Anderson Cancer Center (US), University of California, Los Angeles (US), Norton Healthcare (US), Medical College of Wisconsin (US), Moffitt Cancer Center (US), Sarah Cannon (US), University of Miami Health System (US), Allogene Therapeutics (United States) (US), St David's Medical Center (US), Mayo Clinic Hospital (US), Colorado Blood Cancer Institute (US), Sylvester Comprehensive Cancer Center (US), Vanderbilt University Medical Center (US), Stanford University (US)
Good health and well-being
Openalex Percentile: Top 0%
CAR-T cell therapy research
28.23
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