Meta-analysis of Germline Whole-exome Sequencing in 1435 Cases of Testicular Germ Cell Tumour to Evaluate Disruptive Mutations Under Dominant, Recessive, and X-linked Inheritance Models
We investigated samples from 1435 men with testicular cancer and 18 284 men without cancer to compare the rate of disruptive mutations in 19 355 genes. No evidence of specific genes associated with testicular cancer was discovered, although one gene group showed a strong association. Larger studies are needed to identify individual genes associated with causing testicular cancer.
Authors
- Alison Reid (ORCID: https://orcid.org/0000-0001-8567-4941)
- Kevin Litchfield (ORCID: https://orcid.org/0000-0002-3725-0914)
- Richard S. Houlston (ORCID: https://orcid.org/0000-0002-5268-0242)
- Clare Turnbull (ORCID: https://orcid.org/0000-0002-1734-5772)
- Alice Garrett (ORCID: https://orcid.org/0000-0001-8942-283X)
- Zeid Kuzbari
- Robert Anthony Huddart (ORCID: https://orcid.org/0000-0003-3604-1990)
- Peter Broderick (ORCID: https://orcid.org/0000-0002-8348-5829)
- Charlie F Rowlands (ORCID: https://orcid.org/0000-0001-5333-4846)
- Chey Loveday (ORCID: https://orcid.org/0000-0002-2291-372X)
- Isaac Wade
- Subin Choi (ORCID: https://orcid.org/0009-0002-1947-9966)
- Beth Torr
Institutions
- Institute of Cancer Research (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- Cancer Research UK (GB)
- London Cancer (GB)
- CRUK Lung Cancer Centre of Excellence (GB)
- University College London (GB)
Publication Details
- Journal
- European Urology Open Science
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1016/j.euros.2025.01.015
- Citations
- 1
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Movember Foundation
- NIHR Biomedical Research Centre, Royal Marsden NHS Foundation Trust/Institute of Cancer Research
- Cancer Research UK
- National Institute for Health and Care Research
- Institute of Cancer Research