Oral hyoscine butylbromide exerts spasmolytic effects in both gastrointestinal and urogenital tissues in rats
This is the first comparison of PO and IV HBB and atropine in GI and non-GI tissues. Despite low bioavailability, PO HBB accumulated and exerted spasmolytic effects in tissues beyond the GI tract.
Authors
- Marcel Jiménez (ORCID: https://orcid.org/0000-0002-6602-7332)
- Sara Traserra
- Robert Lange (ORCID: https://orcid.org/0000-0002-9500-1238)
- Terence Appelqvist
- Maura Corsetti (ORCID: https://orcid.org/0000-0003-2957-4684)
Institutions
- Universitat Autònoma de Barcelona (ES)
- Nottingham University Hospitals NHS Trust (GB)
- University of Nottingham (GB)
- Sanofi (France) (FR)
- NIHR Nottingham Digestive Diseases Biomedical Research Unit (GB)
- Sanofi (Germany) (DE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1111/bph.17474
- Citations
- 1
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.81
Funders
- Sanofi