Specific immune-inflammatory profiles and neurocognitive deficits predict illness trajectories in people with type 2 diabetes mellitus or psychiatric disorders
Neurocognitive dysfunction and systemic inflammation are associated with prolonged illness trajectories in individuals with psychiatric disorders and T2DM. An immune-inflammatory profile and neurocognitive and functional performance may be valuable to differentiate individuals with different illness trajectories. These findings have potential translational utility for early transdiagnostic interventions targeting these groups.
Authors
- Pau Soldevila-Matías (ORCID: https://orcid.org/0000-0002-9523-7320)
- Jaume Forés-Martos (ORCID: https://orcid.org/0000-0002-9025-4877)
- Gabriel Selva‐Vera (ORCID: https://orcid.org/0000-0001-9895-8361)
- Joan Vicent Sánchez‐Ortí (ORCID: https://orcid.org/0000-0002-8209-6688)
- Vicent Balanzá‐Martínez (ORCID: https://orcid.org/0000-0001-7772-7396)
- Diego Macías Saint-Gerons
- Patricia Correa‐Ghisays (ORCID: https://orcid.org/0000-0002-1752-7349)
- Constanza San Martín Valenzuela (ORCID: https://orcid.org/0000-0003-0347-5442)
- Jon Sánchez-Valle (ORCID: https://orcid.org/0000-0001-7959-6326)
- Inmaculada Fuentes-Durá (ORCID: https://orcid.org/0000-0002-9731-7850)
- Rafael Tabarés‐Seisdedos (ORCID: https://orcid.org/0000-0002-1089-2204)
- Víctor M. Víctor
- Fabián Robledo-Yagüe
- María Flores-Rodero
Institutions
- Universidad de Valladolid (ES)
- Universitat de València (ES)
- Barcelona Supercomputing Center (ES)
- Centro de Investigación Biomédica en Red de Salud Mental (ES)
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
- Hospital Universitario Doctor Peset (ES)
- INCLIVA Health Research Institute (ES)
- Universidad Europea de Madrid (ES)
- Universitat Politècnica de Catalunya (ES)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1016/j.bbih.2025.100962
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Grand Challenges Canada
- Ministerio de Ciencia e Innovación
- Fundación Española para la Ciencia y la Tecnología
- Instituto de Salud Carlos III
- European Regional Development Fund