Novel FKBP prolyl isomerase 1A (FKBP12) ligand promotes functional improvement in SOD1<sup>G93A</sup> amyotrophic lateral sclerosis (ALS) mice
FKBP12 ligands, particularly MP-010, exhibit promising neuroprotective effects in ALS, highlighting their potential as novel therapeutic agents. Further investigations into the molecular mechanisms and clinical translatability of these compounds are needed for their application in ALS treatment.
Authors
- José M. Fuentes (ORCID: https://orcid.org/0000-0001-6910-2089)
- Jose Ignacio Miranda (ORCID: https://orcid.org/0000-0002-7646-6857)
- Rosario Osta (ORCID: https://orcid.org/0000-0001-5687-6704)
- Mireia Herrando‐Grabulosa (ORCID: https://orcid.org/0000-0002-6685-3220)
- Ainara Vallejo‐Illarramendi (ORCID: https://orcid.org/0000-0002-2409-8263)
- Klaudia González-Imaz (ORCID: https://orcid.org/0000-0001-9057-0864)
- Laura Mosqueira‐Martín (ORCID: https://orcid.org/0000-0002-5714-7682)
- Francisco J. Gil‐Bea (ORCID: https://orcid.org/0000-0003-2002-5531)
- Ana Cristina Calvo (ORCID: https://orcid.org/0000-0001-5193-7782)
- J. M. Aizpurua (ORCID: https://orcid.org/0000-0002-1053-5776)
- Núria Gaja‐Capdevila (ORCID: https://orcid.org/0000-0002-0028-570X)
- Laura Moreno‐Martínez (ORCID: https://orcid.org/0000-0002-7277-4318)
- Leticia Moreno‐García (ORCID: https://orcid.org/0000-0003-2436-7205)
- Xavier Navarro (ORCID: https://orcid.org/0000-0001-9849-902X)
- Laura Rodríguez-Gómez (ORCID: https://orcid.org/0000-0002-3789-3370)
- Abraham Acevedo‐Arozena (ORCID: https://orcid.org/0000-0001-6127-7116)
- Maialen Sagartzazu‐Aizpurua (ORCID: https://orcid.org/0000-0003-3711-9884)
- Adolfo López de Munaín
Institutions
- Ikerbasque (ES)
- Universitat Autònoma de Barcelona (ES)
- University of the Basque Country (ES)
- Universidad de Zaragoza (ES)
- Hospital Universitario de Canarias (ES)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Biogipuzkoa Health Research Institute (ES)
- Instituto de Investigación Biosanitaria de Granada (ES)
- Centro de Investigación y Tecnología Agroalimentaria de Aragón (ES)
- Instituto de Investigación Sanitaria Aragón (ES)
- Universidad de Extremadura (ES)
- Universidad de Navarra (ES)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1111/bph.17448
- Citations
- 2
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 2.78
Funders
- European Commission
- Eusko Jaurlaritza
- Euskal Herriko Unibertsitatea
- Ikerbasque, Basque Foundation for Science
- Universidad Pública de Navarra
- Instituto de Salud Carlos III
- European Regional Development Fund
- Agencia Estatal de Investigación
- European Social Fund