Human responses to the DNA prime/chimpanzee adenovirus (ChAd63) boost vaccine identify CSP, AMA1 and TRAP MHC Class I-restricted epitopes
This integrated approach using immunoassays and bioinformatics identified and confirmed AMA1-MHC Class I-restricted epitopes and a list of predicted additional epitopes which could be evaluated in future studies to assess possible association with protection against CHMI in the Phase 1 trial participants. The results suggest that identification of protection-associated epitopes within malaria antigens is feasible and can help design potent next generation multi-antigen, multi-epitope malaria vaccines for a genetically diverse population and to develop robust assays to measure protective cellular immunity against pre-erythrocytic stages of malaria. This approach can be used to develop vaccines for other novel emerging infectious disease pathogens.
Authors
- Lorraine Soisson
- Martha Sedegah (ORCID: https://orcid.org/0000-0001-6385-508X)
- Christopher Duplessis (ORCID: https://orcid.org/0000-0003-3489-0913)
- Noelle B. Patterson
- Rachel Velasco (ORCID: https://orcid.org/0000-0003-0356-252X)
- Arnel Belmonte (ORCID: https://orcid.org/0000-0002-1738-6240)
- Bjoern Peters (ORCID: https://orcid.org/0000-0002-8457-6693)
- Marvin J. Sklar (ORCID: https://orcid.org/0000-0003-4109-8924)
- María Belmonte (ORCID: https://orcid.org/0000-0002-4103-6611)
- Keith Limbach
- Sandra Inoue
- Judith E. Epstein (ORCID: https://orcid.org/0000-0001-9381-7607)
- Jun Huang (ORCID: https://orcid.org/0000-0002-7837-653X)
- Kimberly A. Edgel
- Michael R. Hollingdale (ORCID: https://orcid.org/0000-0002-2343-3824)
- Santina Maiolatesi
- Eileen Villasante
- Harini Ganeshan (ORCID: https://orcid.org/0009-0000-8989-006X)
Institutions
- Henry M. Jackson Foundation (US)
- National Institutes of Health (US)
- La Jolla Institute for Immunology (US)
- Naval Medical Research Command (US)
- General Dynamics (United States) (US)
- United States Agency for International Development (US)
- National Institute of Allergy and Infectious Diseases (US)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1371/journal.pone.0318098
- Citations
- 2
- Primary Topic
- vaccines and immunoinformatics approaches
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- U.S. Department of Defense
- United States Agency for International Development
- Henry M. Jackson Foundation
- National Institutes of Health
- U.S. Navy
- National Medical Research Council
- National Institute of Allergy and Infectious Diseases