Spatial distribution of Plasmodium vivax Duffy Binding Protein copy number variation and Duffy genotype, and their association with parasitemia in Ethiopia
A high proportion of P. vivax infection was observed in Duffy positives in this study, yet few Duffy negatives were found infected with P. vivax. The significant prevalence of multi-copy PvDBP observed among Ethiopian P. vivax isolates explains the high prevalence and parasitemia observed in clinical cases. This suggests that vivax malaria is a public health concern in the country where the Duffy positive population predominates. Investigating the relative contribution to the maintenance of the infectious reservoir of infections with different genotyping backgrounds (both host and parasite) might be required.
Authors
- Eshetu Molla (ORCID: https://orcid.org/0000-0001-8262-0622)
- Wakweya Chali (ORCID: https://orcid.org/0000-0002-1180-4480)
- Melat Abdo
- Solomon Sisay (ORCID: https://orcid.org/0000-0003-1965-2837)
- Sisay Dugassa (ORCID: https://orcid.org/0000-0002-6951-3299)
- Tadele Emiru
- Mulugeta Demisse
- Taye H. Hamza (ORCID: https://orcid.org/0000-0002-5330-5671)
- Agajie Likie Bogale (ORCID: https://orcid.org/0000-0002-2794-8251)
- CHRIS J. DRAKELEY (ORCID: https://orcid.org/0000-0003-4863-075X)
- Migbaru Keffale
- Hassen Mamo (ORCID: https://orcid.org/0000-0001-9541-8976)
- Fekadu Massebo (ORCID: https://orcid.org/0000-0002-1442-9567)
- Dawit Hailu Alemayehu (ORCID: https://orcid.org/0000-0002-4118-8260)
- Fikregabrail Aberra Kassa (ORCID: https://orcid.org/0009-0009-2005-6179)
- Alemayehu Godana Birhanu (ORCID: https://orcid.org/0000-0001-5302-0919)
- Legesse Alamerie Ejigu
- Lina Alemayehu
- Zufan Yiheyis Abriham (ORCID: https://orcid.org/0009-0009-9220-1857)
- Endalamaw Gadisa (ORCID: https://orcid.org/0000-0002-5179-6278)
- Fitsum G. Tadesse (ORCID: https://orcid.org/0000-0003-1931-1442)
- Cristian Koepfli (ORCID: https://orcid.org/0000-0002-9354-0414)
- Tadesse Misganaw (ORCID: https://orcid.org/0000-0001-7994-3797)
- Jimma Dinsa Deressa
- Getnet Habtamu
- Yasin Nasir
- Alemayehu Letebo
- Abel Beliyu Tamirat
Institutions
- University of Notre Dame (US)
- Madda Walabu University (ET)
- London School of Hygiene & Tropical Medicine (GB)
- Kotebe University of Education (ET)
- Dilla University (ET)
- Woldia University (ET)
- Armauer Hansen Research Institute (ET)
- Arba Minch University (ET)
- Addis Ababa University (ET)
- University of Gondar (ET)
Publication Details
- Journal
- PLoS neglected tropical diseases
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1371/journal.pntd.0012837
- Citations
- 3
- Primary Topic
- Malaria Research and Control
- Type
- article
- Field-Weighted Citation Impact
- 5.64
Funders
- Bill and Melinda Gates Foundation
- Styrelsen för Internationellt Utvecklingssamarbete
- Wellcome Trust
- Armauer Hansen Research Institute
- Direktoratet for Utviklingssamarbeid