Meriones unguiculatus serves as a spontaneous primary aldosteronism rodent model
The current study reveals that MU could serve as an ideal spontaneous PA model. The increased expression and distribution of CYP11B2 stimulate the excessive aldosterone production in a renin-independent manner, leading to a significant increase in blood pressure in MU.
Authors
- Hexuan Zhang (ORCID: https://orcid.org/0000-0001-6118-8922)
- Min Liu (ORCID: https://orcid.org/0000-0003-0473-2631)
- Zhencheng Yan (ORCID: https://orcid.org/0000-0001-5838-8376)
- Zongshi Lu (ORCID: https://orcid.org/0000-0002-2434-8832)
- Zhiming Zhu (ORCID: https://orcid.org/0000-0003-1035-5588)
- Dan Tong (ORCID: https://orcid.org/0000-0002-7942-6631)
- Qing Zhou (ORCID: https://orcid.org/0000-0002-0478-176X)
- Li Li (ORCID: https://orcid.org/0000-0002-4712-2692)
- Bowen Wang (ORCID: https://orcid.org/0000-0002-0882-8588)
- Lijuan Wang (ORCID: https://orcid.org/0000-0003-1727-2670)
- Peng Dong Gao (ORCID: https://orcid.org/0000-0001-9868-2115)
- Yu Zhao (ORCID: https://orcid.org/0009-0002-6504-527X)
- Mei You
- Zijing Bai (ORCID: https://orcid.org/0000-0002-8014-0534)
- Tingbing Cao
Institutions
- Army Medical University (CN)
- Daping Hospital (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1371/journal.pone.0314943
- Primary Topic
- Hormonal Regulation and Hypertension
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Chongqing