Evolutionary convergence of sensory circuits in the pallium of amniotes
The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA and spatial transcriptomics, and mathematical modeling to compare the development and evolution of known pallial circuits across birds (chick), lizards (gecko), and mammals (mouse). We reveal that neurons within these circuits' stations are generated at varying developmental times and brain regions across species and found an early developmental divergence in the transcriptomic progression of glutamatergic neurons. Our research highlights developmental distinctions and functional similarities in the sensory circuit between birds and mammals, suggesting the convergence of high-order sensory processing across amniote lineages.
Authors
- Mats F. Nilsson (ORCID: https://orcid.org/0000-0001-9985-0387)
- Daniel Garrigos (ORCID: https://orcid.org/0000-0003-1337-1321)
- Eneritz Rueda-Alaña (ORCID: https://orcid.org/0000-0003-3045-4970)
- Juan Manuel Encinas (ORCID: https://orcid.org/0000-0002-0402-972X)
- Sergio Marco Salas (ORCID: https://orcid.org/0000-0002-4636-0322)
- Ana Dopazo (ORCID: https://orcid.org/0000-0002-4910-1684)
- Enrique Vázquez (ORCID: https://orcid.org/0000-0003-1157-2592)
- Ana Quintas (ORCID: https://orcid.org/0000-0003-3721-7580)
- Tatiana Gallego‐Flores (ORCID: https://orcid.org/0000-0003-0773-0578)
- Alberto Benguría (ORCID: https://orcid.org/0000-0002-5536-566X)
- Marco Grillo (ORCID: https://orcid.org/0000-0003-2155-0645)
- Fernando García‐Moreno (ORCID: https://orcid.org/0000-0001-9048-4237)
- Ángel Toval (ORCID: https://orcid.org/0000-0003-4798-1216)
- Laura Escobar (ORCID: https://orcid.org/0000-0003-0955-2015)
- Miriam Rábano
- Maurizio De Pittà (ORCID: https://orcid.org/0000-0001-5799-5182)
- Ana M. Aransay (ORCID: https://orcid.org/0000-0002-8271-612X)
- José Luis Ferrán (ORCID: https://orcid.org/0000-0002-3413-9452)
- María dM Vivanco (ORCID: https://orcid.org/0000-0002-9540-247X)
- Rodrigo Senovilla-Ganzo (ORCID: https://orcid.org/0000-0001-6615-0923)
- Artemis Ftara (ORCID: https://orcid.org/0009-0002-9538-2330)
- Aitor Ordeñana-Manso
Institutions
- Ikerbasque (ES)
- University Health Network (CA)
- Stockholm University (SE)
- University of the Basque Country (ES)
- University of Toronto (CA)
- Science for Life Laboratory (SE)
- Basque Center for Applied Mathematics (ES)
- Spanish National Centre for Cardiovascular Research (ES)
- Centro de Investigación en Red en Enfermedades Cardiovasculares (ES)
- Achucarro Basque Center for Neuroscience (ES)
- CIC bioGUNE (ES)
- Centro de Investigación Biomédica en Red (ES)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Krembil Research Institute
- Universidad de Murcia (ES)
Publication Details
- Journal
- Science
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1126/science.adp3411
- Citations
- 27
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 21.76