Arcyriaflavin A, a cyclin D1/CDK4 inhibitor, suppresses tumor growth, migration, and invasion of metastatic melanoma cells
Collectively, our findings indicate that ArcA possesses substantial anti-tumor potential, including cytotoxic effects and inhibition of migration and invasion in metastatic melanoma. These results suggest that ArcA could enhance therapeutic efficacy in the treatment of metastatic melanoma.
Authors
- Yeun‐Jun Chung (ORCID: https://orcid.org/0000-0002-6943-5948)
- Songzi Zhang (ORCID: https://orcid.org/0000-0003-2082-0017)
- Minyoung Park (ORCID: https://orcid.org/0000-0003-4628-147X)
- Dokyeong Kim (ORCID: https://orcid.org/0000-0002-5154-9613)
- Junseong Park (ORCID: https://orcid.org/0000-0003-0436-8614)
- Yoon‐Seob Kim (ORCID: https://orcid.org/0000-0003-1660-010X)
- Sumin Cho
- Okcho Na
Institutions
- The Catholic University of Korea Bucheon St. Mary's Hospital (KR)
- Catholic University of Korea (KR)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1186/s12935-025-03675-4
- Primary Topic
- Melanoma and MAPK Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea