RNA Sequence Analysis in Macrophages Infected With <i>Trypanosoma cruzi</i>: Focus on TLR2 and TLR7, Iron Metabolism, and Extracellular Matrix Biosynthesis
Our study recapitulates knowledge on the response of macrophages and provides insights into the importance of TLR2 and TLR7, iron metabolism, and extracellular matrix in the infected macrophage, which help the understanding of molecular mechanisms underlying T. cruzi infection in macrophages with strains with different virulence. These findings are crucial for identifying novel therapeutic targets and advancing strategies to combat Chagas disease.
Authors
- Alfonso Herreros‐Cabello (ORCID: https://orcid.org/0000-0002-1137-891X)
- Núria Gironès (ORCID: https://orcid.org/0000-0002-8130-2750)
- Cristina Poveda (ORCID: https://orcid.org/0000-0003-0361-2232)
- Manuel Fresno (ORCID: https://orcid.org/0000-0002-9223-5477)
- Francisco Callejas‐Hernández (ORCID: https://orcid.org/0000-0002-2378-3904)
- María del Carmen Lapo Maza
- José Francisco Mares (ORCID: https://orcid.org/0000-0002-1981-9003)
- Diana Karolina Santos-Peñaloza
Institutions
- Johns Hopkins University (US)
- Hospital Universitario de La Princesa (ES)
- Centro de Biología Molecular Severo Ochoa (ES)
- Universidad Autónoma de Madrid (ES)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1093/infdis/jiaf074
- Primary Topic
- Trypanosoma species research and implications
- Type
- article
- Field-Weighted Citation Impact
- 0.00