Quorum quenching enzymes disrupt bacterial communication in a sex‐ and dose‐dependent manner
Overall, our study establishes proof of concept that QQ is a targetable strategy for microbial control in vivo. Further characterization and dosage optimization of QQ enzymes are necessary to harness their therapeutic capability for the treatment of chronic microbial-associated diseases.
Authors
- Rakesh Sikdar (ORCID: https://orcid.org/0000-0001-9795-8028)
- Matthew Dietz
- Mikael Elias (ORCID: https://orcid.org/0000-0003-0406-7539)
- Marı́a Martell (ORCID: https://orcid.org/0000-0002-0935-0029)
- Christopher M. Staley (ORCID: https://orcid.org/0000-0002-2309-0083)
- Cyrus Jahansouz (ORCID: https://orcid.org/0000-0002-7884-2799)
- Zachary Ziegert (ORCID: https://orcid.org/0009-0001-7625-3800)
- Aneesh Syal
Institutions
- University of Minnesota (US)
- Biotechnology Institute (US)
Publication Details
- Journal
- Animal Models and Experimental Medicine
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1002/ame2.12520
- Citations
- 1
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- University of Minnesota
- Genomics Center, University of Minnesota