Anti-inflammatory and Hepatoprotective Iridoid Glycosides from the Roots of <i>Gomphandra mollis</i>
Ten previously undescribed iridoid glycosides (<b>1</b>-<b>10</b>), including monoiridoids, hybrid iridoid-alkaloids, bis-iridoids, noriridoid-iridoid dimers, and tetramers, were isolated from the roots of <i>Gomphandra mollis</i> Merr. Structural elucidation revealed unique sugar chains not previously observed for iridoids and complex tetrameric configurations that are rare in nature. Compounds <b>9</b>, <b>10</b>, and <b>15</b> demonstrated significant anti-inflammatory effects, with IC<sub>50</sub> values ranging from 6.13 to 13.0 μM, and compounds <b>6</b>, <b>7</b>, and <b>11</b>-<b>13</b> showed notable hepatoprotective activity in HepG2 cells. Additionally, structure-activity relationship (SAR) analysis on anti-inflammatory effects was also conducted. This study enriches the structural database of iridoids, particularly complex derivatives, and highlights their therapeutic potential in addressing inflammation-related and liver diseases.
Authors
- Yunhan Wang (ORCID: https://orcid.org/0000-0001-8823-0326)
- Su-Jung Hsu
- Man-Hsiu Chu
- Thanh‐Hoa Vo (ORCID: https://orcid.org/0000-0002-6044-1911)
- Ching‐Kuo Lee (ORCID: https://orcid.org/0000-0003-2827-396X)
- Dang-Khoa Nguyen (ORCID: https://orcid.org/0000-0002-6681-7609)
- Ta-Wei Liu (ORCID: https://orcid.org/0000-0002-4286-2210)
- Thanh-Vu Nguyen (ORCID: https://orcid.org/0000-0003-0721-7651)
- Thuy-Tien Thi Phan
- Truc-Ly Thi Duong (ORCID: https://orcid.org/0009-0002-2063-5938)
- Quoc-Dung Tran Huynh (ORCID: https://orcid.org/0009-0005-0908-3433)
- Bien-Thuy Nguyen Bui
Institutions
- Vietnam National University Ho Chi Minh City (VN)
- Ton Duc Thang University (VN)
- Chung Yuan Christian University (TW)
- National Taiwan University (TW)
- University of Health Science (KH)
- Can Tho University (VN)
- Biotechnology Research Center (IR)
- National Research Institute of Chinese Medicine (TW)
- Bình Dương University (VN)
- Ministry of Health and Welfare (TW)
- Institute of Fisheries and Aquaculture (BG)
- Center for Discovery (US)
- Kyiv Institute of Traditional Medicine (UA)
- Institute of Pharmacology (CZ)
- Taipei Medical University (TW)
Publication Details
- Journal
- Journal of Natural Products
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1021/acs.jnatprod.4c01484
- Citations
- 2
- Primary Topic
- Phytochemistry and Biological Activities
- Type
- article
- Field-Weighted Citation Impact
- 3.50
Funders
- Ministry of Science and Technology, Taiwan
- Taipei Medical University
- National Taiwan University