Dachaihu decoction ameliorates abnormal behavior by regulating gut microbiota in rats with propionic acid-induced autism
This study demonstrated that DCHD may alleviate ASD via inhibiting oxidative stress, reducing inflammation, and modulating the gut microbiota in rats. Combined with human trial, DCHD may be a promising drug for treating ASD. This study provides a scientific rationale for treating mental disorders related to gut microbiota dysbiosis.
Authors
- Bao-Qi Yin
- Hang Li (ORCID: https://orcid.org/0000-0003-2920-0025)
- Enyao Li (ORCID: https://orcid.org/0000-0002-9357-0875)
- Xuejun Chai (ORCID: https://orcid.org/0000-0002-5590-4328)
- Pengya Feng
- Honglei Li (ORCID: https://orcid.org/0000-0001-8381-2888)
- Yangyang Zhang (ORCID: https://orcid.org/0000-0003-3754-8291)
- Bolin Li (ORCID: https://orcid.org/0000-0002-6733-2179)
- Xue Xia (ORCID: https://orcid.org/0000-0001-9697-3840)
- Youcai Tang (ORCID: https://orcid.org/0000-0002-9537-2397)
- Sheng Li (ORCID: https://orcid.org/0009-0007-1820-3446)
- Yong-Hong Zhao
- Yizhuang Li
- Pengju Zhao
Institutions
- Fujian University of Traditional Chinese Medicine (CN)
- Westlake University (CN)
- Xi'an Medical University (CN)
- Fifth Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-02-13
- DOI
- https://doi.org/10.3389/fmicb.2025.1535451
- Citations
- 5
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 4.03
Funders
- Henan Provincial Science and Technology Research Project