Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation

Our findings identified EGFRvIII-positive CRC as a distinct subtype characterized by adenosine-mediated immunosuppressive TME. Targeting adenosine significantly improved the efficacy of anti-PD-1 in MSS CRC.

Authors

Institutions

Publication Details

Journal
Journal for ImmunoTherapy of Cancer
Published
2025-02-01
DOI
https://doi.org/10.1136/jitc-2024-010126
Citations
6
Primary Topic
Cancer Immunotherapy and Biomarkers
Type
article
Field-Weighted Citation Impact
6.27

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation

Na Huang, Chunting Zeng, Zhiqi Yao, Min Shi et al.
6 citations
Journal for ImmunoTherapy of Cancer
Cancer Immunotherapy and Biomarkers
6.27
article

Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation

Na Huang, Chunting Zeng, Zhiqi Yao, Min Shi, Wangjun Liao, Yujing Tan, Jing Wu, Qiong Huang, Xiaoxiang Rong, Qijing Wu, Fangzhen Yao, Chunhui Gu, Yulu Shi, Yawen Wang, Yong Li, Fei Sun, Jiao Wang, Yang Zhao, Chunlin Wang, Shaowei Li, Yu Jiang, Jianjun Peng, Bishan Liang
article en
6 citations

Abstract

Our findings identified EGFRvIII-positive CRC as a distinct subtype characterized by adenosine-mediated immunosuppressive TME. Targeting adenosine significantly improved the efficacy of anti-PD-1 in MSS CRC.

Journal for ImmunoTherapy of CancerVol. 13(2)
The University of Texas MD Anderson Cancer Center (US), Sun Yat-sen University (CN), Nanfang Hospital (CN), First People's Hospital of Foshan (CN), Guangdong Provincial Hospital of Traditional Chinese Medicine (CN), Zhujiang Hospital (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Southern Medical University (CN)
National Natural Science Foundation of China, Basic and Applied Basic Research Foundation of Guangdong Province
Good health and well-being
Openalex Percentile: Top 4%
Cancer Immunotherapy and Biomarkers
6.27
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.