Targeting adenosine enhances immunotherapy in MSS colorectal cancer with EGFRvIII mutation
Our findings identified EGFRvIII-positive CRC as a distinct subtype characterized by adenosine-mediated immunosuppressive TME. Targeting adenosine significantly improved the efficacy of anti-PD-1 in MSS CRC.
Authors
- Na Huang (ORCID: https://orcid.org/0000-0001-7961-0677)
- Chunting Zeng
- Zhiqi Yao (ORCID: https://orcid.org/0009-0007-7803-4357)
- Min Shi (ORCID: https://orcid.org/0000-0003-0113-4089)
- Wangjun Liao (ORCID: https://orcid.org/0000-0002-1364-8442)
- Yujing Tan (ORCID: https://orcid.org/0000-0001-8781-1209)
- Jing Wu (ORCID: https://orcid.org/0000-0002-2492-5118)
- Qiong Huang (ORCID: https://orcid.org/0000-0002-0570-5961)
- Xiaoxiang Rong (ORCID: https://orcid.org/0000-0002-5058-2067)
- Qijing Wu (ORCID: https://orcid.org/0000-0003-1712-124X)
- Fangzhen Yao
- Chunhui Gu
- Yulu Shi (ORCID: https://orcid.org/0000-0001-5843-5128)
- Yawen Wang (ORCID: https://orcid.org/0000-0002-5369-7660)
- Yong Li (ORCID: https://orcid.org/0000-0001-8838-1714)
- Fei Sun (ORCID: https://orcid.org/0000-0002-0351-5144)
- Jiao Wang (ORCID: https://orcid.org/0000-0003-0296-6522)
- Yang Zhao (ORCID: https://orcid.org/0000-0003-4184-0375)
- Chunlin Wang (ORCID: https://orcid.org/0000-0003-4807-1644)
- Shaowei Li (ORCID: https://orcid.org/0000-0002-3374-1038)
- Yu Jiang
- Jianjun Peng (ORCID: https://orcid.org/0000-0002-5869-8013)
- Bishan Liang
Institutions
- The University of Texas MD Anderson Cancer Center (US)
- Sun Yat-sen University (CN)
- Nanfang Hospital (CN)
- First People's Hospital of Foshan (CN)
- Guangdong Provincial Hospital of Traditional Chinese Medicine (CN)
- Zhujiang Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2025-02-01
- DOI
- https://doi.org/10.1136/jitc-2024-010126
- Citations
- 6
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 6.27
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province