Severe subacute combined degeneration of the spinal cord resulting from nitrous oxide (N2O) abuse: a case series
N2O abuse over a few weeks can lead to severe SACD. The diagnosis is supported by characteristic findings on spinal MRI and elevated methylmalonic acid levels, while normal vitamin B12 levels do not rule out N2O-induced SACD. Although there was some clinical improvement upon cessation of N2O abuse and vitamin B12 supplementation, residual deficits persisted.
Authors
- Klemens Ruprecht (ORCID: https://orcid.org/0000-0003-1962-6014)
- Lucas C. Adam (ORCID: https://orcid.org/0000-0001-9067-1710)
- Katrin Hahn (ORCID: https://orcid.org/0000-0002-6013-0072)
- Patricia Krause (ORCID: https://orcid.org/0000-0001-9063-0556)
- Christiana Franke (ORCID: https://orcid.org/0000-0002-5609-2472)
- Heinrich J. Audebert (ORCID: https://orcid.org/0000-0002-4785-0366)
- Anuschka Grobelny
Institutions
- Humboldt-Universität zu Berlin (DE)
- Freie Universität Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Neurological Research and Practice
- Published
- 2025-02-12
- DOI
- https://doi.org/10.1186/s42466-024-00364-x
- Citations
- 4
- Primary Topic
- Folate and B Vitamins Research
- Type
- article
- Field-Weighted Citation Impact
- 6.67
Funders
- Charité – Universitätsmedizin Berlin