Evaluating the effectiveness of medical therapy in infantile epileptic spasms syndrome due to surgically‐remediable lesions
Although two-thirds of surgically-remediable IESS exhibited an initial response to medical therapy, relapses were frequent. The majority progressed to DRE during follow-up, particularly those with younger age at IESS onset, congenital-structural etiology, or extensive MRI abnormalities. Patients at risk for DRE can be recognized early by the lack of response to first standard therapy (OR 4.15). Our findings can help reduce delays for surgical referral in patients with surgically-remediable IESS.
Authors
- Mark H. Libenson
- Aristides Hadjinicolaou (ORCID: https://orcid.org/0000-0002-9926-2080)
- Stephanie Donatelli
- Scellig S. D. Stone (ORCID: https://orcid.org/0000-0002-4546-6790)
- Catherine L. Salussolia (ORCID: https://orcid.org/0000-0003-0168-3205)
- Debopam Samanta (ORCID: https://orcid.org/0000-0002-5154-8717)
- Christina Briscoe Abath (ORCID: https://orcid.org/0000-0002-1026-7695)
- Alexandra Santana Almansa (ORCID: https://orcid.org/0009-0009-3550-1263)
- Avantika Singh (ORCID: https://orcid.org/0000-0002-7261-1543)
- Bo Zhang (ORCID: https://orcid.org/0000-0003-1574-198X)
- Nishtha Gupta
- Chellamani Harini (ORCID: https://orcid.org/0000-0002-1452-5065)
- Jeffrey Bolton (ORCID: https://orcid.org/0000-0003-2949-8722)
Institutions
- Children's Hospital of Wisconsin (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Medical College of Wisconsin (US)
- University of Arkansas for Medical Sciences (US)
Publication Details
- Journal
- Epilepsia
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1111/epi.18291
- Citations
- 4
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.88