A natural biological adhesive from slug mucus for wound repair
Slugs could secrete mucus with multifunctional characteristics, such as reversible gelation, mucoadhesiveness, and viscoelasticity, which can be harnessed for multifaceted biotechnological and healthcare applications. The dried mucus (DM) was prepared using slug, which can be adhered to the tissue surface through different types of interactions (lap-shear force, 1.1 N for DM-3 group). The DM-3 further exhibited the highest hemostatic ability as discerned in a liver trauma injury model (hemostasis time, <15 s), biocompatibility and biodegradability (an insignificant residue at 4 weeks) <i>in vivo</i>, and considerably improved skin repair in full-thickness excisional wounds (wound closure, 96.2 % at day 14). Taken together, slug's mucus can be easily prepared with an economic and an eco-friendly method, which may have broad biotechnological and healthcare implications and potential utility in other related disciplines. This transition from natural components to the biomaterial may provide an invaluable platform for different types of applications.
Authors
- Zhengchao Yuan (ORCID: https://orcid.org/0009-0001-3797-2511)
- Siyuan Wu (ORCID: https://orcid.org/0000-0002-4826-1010)
- Liwen Fu
- Shichao Jiang (ORCID: https://orcid.org/0000-0002-2859-5742)
- Xiumei Mo (ORCID: https://orcid.org/0000-0001-9238-6171)
- Meera Moydeen Abdulhameed (ORCID: https://orcid.org/0000-0001-5394-7933)
- Yuanming Xu (ORCID: https://orcid.org/0000-0001-6759-1851)
- Hao Feng (ORCID: https://orcid.org/0000-0002-3284-5863)
- Xinyi Wang (ORCID: https://orcid.org/0000-0003-1780-7719)
- Muhammad Shafiq (ORCID: https://orcid.org/0000-0002-5887-5032)
- Jiahui Song (ORCID: https://orcid.org/0000-0002-9331-2139)
- Zewen Wang
- Lu Han (ORCID: https://orcid.org/0000-0002-1753-0732)
- Mohamed EL-Newehy (ORCID: https://orcid.org/0000-0002-4265-0701)
Institutions
- Donghua University (CN)
- Shanghai Jiao Tong University (CN)
- King Saud University (SA)
- Innovation Center of NanoMedicine (JP)
- Shandong Provincial Hospital (CN)
- Xinqiao Hospital (CN)
- Shanghai First People's Hospital (CN)
- Shanghai Institute of Quality Inspection and Technical Research (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2025-02-13
- DOI
- https://doi.org/10.1016/j.bioactmat.2025.01.030
- Citations
- 7
- Primary Topic
- Surgical Sutures and Adhesives
- Type
- article
- Field-Weighted Citation Impact
- 14.04
Funders
- King Saud University
- China Postdoctoral Science Foundation
- Science and Technology Commission of Shanghai Municipality
- Natural Science Foundation of Shandong Province
- Chinesisch-Deutsche Zentrum für Wissenschaftsförderung
- Taishan Scholar Foundation of Shandong Province
- Fundamental Research Funds for Central Universities of the Central South University